Evaluation of biologically relevant short alpha-helices stabilized by a main-chain hydrogen-bond surrogate.

Evaluation of biologically relevant short alpha-helices stabilized by a main-chain hydrogen-bond surrogate. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Evaluation of biologically relevant short alpha-helices stabilized by a main-chain hydrogen-bond surrogate. Abstract Text:

Deyun Wang,Kang Chen,John L Kulp Iii,Paramjit S Arora,

We previously reported the design and synthesis of a new class of artificial alpha-helices in which an N-terminal main-chain hydrogen bond is replaced by a carbon-carbon bond derived from a ring-closing metathesis reaction [Chapman, R. N.; Dimartino, G.; Arora, P. S. J. Am. Chem. Soc. 2004, 126, 12252-12253]. Our initial study utilized an alanine-rich sequence; in the present manuscript we evaluate the potential of this method for the synthesis of very short (10 residues) alpha-helices representing two different biologically relevant alpha-helical domains. We extensively characterized these two sets of artificial helices by NMR and circular dichroism spectroscopies and find that the hydrogen-bond surrogate approach can afford well-defined short alpha-helical structures from sequences that do not spontaneously form alpha-helical conformations.

Evaluation of biologically relevant short alpha-helices stabilized by a main-chain hydrogen-bond surrogate. Publishing Authors By Initials

D Wang,K Chen,JL Kulp Iii,PS Arora,

For similar proteins research abstracts see: proteins research

PUBMED ID PMID:

MEDLINE DATE:

Evaluation of biologically relevant short alpha-helices stabilized by a main-chain hydrogen-bond surrogate. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of the American Chemical Society

VOLUME: 128

Page Numbers: 9248-56

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 19

MONTH: Jul

YEAR: 2006

Evaluation of biologically relevant short alpha-helices stabilized by a main-chain hydrogen-bond surrogate. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7503056

Evaluation of biologically relevant short alpha-helices stabilized by a main-chain hydrogen-bond surrogate. Keywords Mesh Terms:

KEYWORDS: Proteins

MESH TERMS: chemistry

Chemical & Substance for Abstract: Evaluation of biologically relevant short alpha-helices stabilized by a main-chain hydrogen-bond surrogate. Information

Substance Name: Proteins

Registry Number: 0

Grant and Affiliation Information for Evaluation of biologically relevant short alpha-helices stabilized by a main-chain hydrogen-bond surrogate.

AFFILIATION: Department of Chemistry, New York University, New York, New York 10003, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: R01 GM073943-02

ACRONYM: GM

MEDLINETA: J Am Chem Soc

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Evaluation of biologically relevant short alpha-helices stabilized by a main-chain hydrogen-bond surrogate Related Publications

• A multicenter, prospective, open-label, non-comparative study to evaluate the immunogenicity and tolerance of a new, fully liquid pentavalent vaccine (DTwP-HepB-Hib vaccine).
• Biological warfare: Bioterrorism.
• Cardiovascular risk with subclinical hyperthyroidism and hypothyroidism: pathophysiology and management.
• Changing resistance pattern of shigella isolates in a Delhi hospital: An alarming trend.
• Dal water as weaning food: a common but inappropriate practice.
• Determination of baseline widal titres from Chandigarh.
• Ethics in laboratory medicine.
• Evaluation of biologically relevant short alpha-helices stabilized by a main-chain hydrogen-bond surrogate.
• Evaluation of the safety of modafinil for treatment of excessive sleepiness.
• HIV seropositivity among patients with sexually transmitted diseases.
• HIV-1 therapeutic vaccine: A ray of hope.
• In vitro activity of linezolid in staphylococcus aureus.
• Intrapartum amnioinfusion for meconium-stained amniotic fluid: a systematic review of randomised controlled trials.
• Low temperature incubation improves the performance of anti-phenolic glycolipid-I antibody detecting ELISA in leprosy patients.
• Microbial flora in orodental infections.
• Nucleation and stability of hydrogen-bond surrogate-based alpha-helices.
• Optimized synthesis of hydrogen-bond surrogate helices: surprising effects of microwave heating on the activity of Grubbs catalysts.
• Potable groundwater quality in some villages of Haryana, India: focus on fluoride.
• Preemptive antiemesis in patients undergoing modified radical mastectomy: oral granisetron versus oral ondansetron in a double-blind, randomized, controlled study.
• Promoting an environment of professionalism: the University of Chicago "Roadmap".
• Protective Effect of 3-ss-Hydroxy-2,3-dihydrowithanolide F against CCl4-induced Hepatotoxicity.
• Quality assurance in microbiology.
• Role of anaerobes in acute pelvic inflammatory disease.
• Screening by VDRL test to detect hidden cases of syphilis.
• Silent perforation: an iatrogenic complication of colonoscopy.
• Solution- and solid-phase synthesis of triazole oligomers that display protein-like functionality.
• The divergent TGF-beta ligand Dawdle utilizes an activin pathway to influence axon guidance in Drosophila.
• Tissue angiotensin-converting enzyme inhibitors for the prevention of cardiovascular disease in patients with diabetes mellitus without left ventricular systolic dysfunction or clinical evidence of heart failure: a pooled meta-analysis of randomized place
• Widening the door: the evolution of hepatitis C treatment in patients with psychiatric disorders.
• Zero delay synchronization of chaos in coupled map lattices.