Evaluation of antileishmanial potential of Tinospora sinensis against experimental visceral leishmaniasis.

Evaluation of antileishmanial potential of Tinospora sinensis against experimental visceral leishmaniasis. Research Abstract Details 

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Evaluation of antileishmanial potential of Tinospora sinensis against experimental visceral leishmaniasis. Abstract Text:

Nasib Singh,Awanish Kumar,Prasoon Gupta,Kailash Chand,Mukesh Samant,Rakesh Maurya,Anuradha Dube,

The chemotherapeutic interventions against visceral leishmaniasis (VL) are limited and facing serious concerns of toxicity, high cost, and emerging drug resistance. There is a greater interest in new drug developments from traditionally used medicinal plants which offers unprecedented diversity in structures and bioactivity. With this rationale, ethanolic extract of Tinospora sinensis Linn and its four fractions were tested in vitro against promastigotes and intracellular amastigotes and in vivo in Leishmania donovani infected hamsters. Ethanolic extract exhibited an appreciable activity against promastigotes (IC(50) 37.6 +/- 6.2 mug/ml) and intracellular amastigotes (IC(50) 29.8 +/- 3.4 mug/ml). In hamsters, it resulted in 76.2 +/- 9.2% inhibition at 500 mg/kg/day x 5 oral dose level. Among fractions, n-butanol imparted highest in vitro and in vivo activities. Ethanolic extract and butanol fraction also enhances reactive oxygen species (ROS) and nitric oxide (NO) release. The results indicate that T. sinensis may provide new lead molecules for the development of alternative drugs against VL.

Evaluation of antileishmanial potential of Tinospora sinensis against experimental visceral leishmaniasis. Publishing Authors By Initials

N Singh,A Kumar,P Gupta,K Chand,M Samant,R Maurya,A Dube,

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Evaluation of antileishmanial potential of Tinospora sinensis against experimental visceral leishmaniasis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Parasitology research

VOLUME: 102

Page Numbers: 561-5

Journal Abbreviation: Parasitol. Res.

ISSN: 0932-0113

DAY: 13

MONTH: 12

YEAR: 2007

Evaluation of antileishmanial potential of Tinospora sinensis against experimental visceral leishmaniasis. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Evaluation of antileishmanial potential of Tinospora sinensis against experimental visceral leishmaniasis.

AFFILIATION: Division of Parasitology, Central Drug Research Institute, Lucknow, 226 001, India, anuradha_dube@rediffmail.com.

Country: Germany

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MEDLINETA: Parasitol Res

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