Evaluation of a computer-based system for plus disease diagnosis in retinopathy of prematurity.

Evaluation of a computer-based system for plus disease diagnosis in retinopathy of prematurity. Research Abstract Details 

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Evaluation of a computer-based system for plus disease diagnosis in retinopathy of prematurity. Abstract Text:

Susan Koreen,Rony Gelman,M Elena Martinez-Perez,Lei Jiang,Audina M Berrocal,Ditte J Hess,John T Flynn,Michael F Chiang,Susan Koreen,Rony Gelman,M Elena Martinez-Perez,Lei Jiang,Audina M Berrocal,Ditte J Hess,John T Flynn,Michael F Chiang,Susan Koreen,Rony Gelman,M Elena Martinez-Perez,Lei Jiang,Audina M Berrocal,Ditte J Hess,John T Flynn,Michael F Chiang,

OBJECTIVE: To measure accuracy and reliability of the computer-based Retinal Image Multiscale Analysis (RISA) system compared with those of recognized retinopathy of prematurity (ROP) experts, for plus disease diagnosis. DESIGN: Evaluation of diagnostic test or technology. PARTICIPANTS: Eleven recognized ROP experts and the RISA image analysis system interpreted a set of 20 wide-angle retinal photographs for presence of plus disease. METHODS: All experts used a secure Web site to review independently 20 images for presence of plus disease. Images were also analyzed by measuring individual computer-based system parameters (integrated curvature [IC], diameter, and tortuosity index) for arterioles and venules and by computing linear combinations and logical combinations of those parameters. Performance was compared with a reference standard, defined as the majority vote of experts. MAIN OUTCOME MEASURES: Diagnostic accuracy was measured by calculating sensitivity, specificity, and receiver operating characteristic area under the curve (AUC) for plus disease diagnosis by each expert, and by each computer-based system parameter, compared with the reference standard. Diagnostic agreement was measured by calculating the mean kappa value of each expert compared with all other experts and the mean kappa value of each computer-based system parameter compared with all experts. RESULTS: Among the 11 experts, sensitivity ranged from 0.167 to 1.000, specificity ranged from 0.714 to 1.000, AUC ranged from 0.798 to 1.000, and mean kappa compared with all other experts ranged from 0.288 to 0.689. Among individual computer system parameters, arteriolar IC had the highest diagnostic accuracy, with sensitivity of 1.000; specificity, 0.846; and AUC, 0.962. Arteriolar IC had the highest diagnostic agreement with experts, with a mean kappa value of 0.578. CONCLUSIONS: A computer-based image analysis system has the potential to perform comparably to recognized ROP experts for plus disease diagnosis.

Evaluation of a computer-based system for plus disease diagnosis in retinopathy of prematurity. Publishing Authors By Initials

S Koreen,R Gelman,ME Martinez-Perez,L Jiang,AM Berrocal,DJ Hess,JT Flynn,MF Chiang,S Koreen,R Gelman,ME Martinez-Perez,L Jiang,AM Berrocal,DJ Hess,JT Flynn,MF Chiang,S Koreen,R Gelman,ME Martinez-Perez,L Jiang,AM Berrocal,DJ Hess,JT Flynn,MF Chiang,

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Evaluation of a computer-based system for plus disease diagnosis in retinopathy of prematurity. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Ophthalmology

VOLUME: 114

Page Numbers: e59-67

Journal Abbreviation: Ophthalmology

ISSN: 1549-4713

DAY: 6

MONTH: Dec

YEAR: 2007

Evaluation of a computer-based system for plus disease diagnosis in retinopathy of prematurity. Information

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LANGUAGE: eng

NlmUniqueID: 7802443

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Grant and Affiliation Information for Evaluation of a computer-based system for plus disease diagnosis in retinopathy of prematurity.

AFFILIATION: Department of Ophthalmology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA.

Country: United States

AGENCY: United States NEI

GRANT: EY13972

ACRONYM: EY

MEDLINETA: Ophthalmology

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