Etiology of decreased gastric nitric oxide in the critically ill.

Etiology of decreased gastric nitric oxide in the critically ill. Research Abstract Details 

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Etiology of decreased gastric nitric oxide in the critically ill. Abstract Text:

Michel A Boivin,Christopher A Fiack,John C Kennedy,Gary K Iwamoto,

BACKGROUND: Nitric oxide (NO) is present in the gas phase of the normal human stomach at a high concentration (1-10 ppm). The majority of this NO is produced from the reduction of dietary nitrate to nitrite and finally NO. Generation of this nonenzymatically produced gastric NO occurs only in an acidic environment. We examined NO concentrations in critically ill subjects and the mechanism for the observed perturbations. METHODS: Seven critically ill, intubated intensive care unit (ICU) patients (mean APACHE II score 16) and seven control patients were studied. Gastric NO concentrations were measured with a Sievers NO analyzer (GE, Boulder, CO). Nitrate and nitrite concentrations were determined by a modified Griess assay. Bacterial counts were determined by optical density at 600 nm. RESULTS: Gastric NO concentration was significantly lower in the critically ill group (102.7 ppb) compared with the control group (953.2 ppb), although this difference was abolished by treating the control group with omeprazole (54 ppb). Gastric nitrate and nitrite concentrations were similar in the control and ICU groups, suggesting that substrate deficiency was not a cause of the low intragastric NO. Gastric pH was significantly lower in the control subjects (3.0) compared with the ICU patients (6.3) and the control subjects after receiving omeprazole (6.5). ICU patients had a trend toward higher gastric bacterial load. CONCLUSION: In critically ill patients, markedly decreased NO concentrations are found in the gas of the stomach owing to a failure of gastric acidification.

Etiology of decreased gastric nitric oxide in the critically ill. Publishing Authors By Initials

MA Boivin,CA Fiack,JC Kennedy,GK Iwamoto,

For similar digestive system: gastrointestinal tract: upper gastrointestinal tract: stomach research abstracts see: digestive system: gastrointestinal tract: upper gastrointestinal tract: stomach research

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Etiology of decreased gastric nitric oxide in the critically ill. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of investigative medicine : the official p

VOLUME: 54

Page Numbers: 484-9

Journal Abbreviation: J. Investig. Med.

ISSN: 1081-5589

DAY: 3

MONTH: Dec

YEAR: 2006

Etiology of decreased gastric nitric oxide in the critically ill. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9501229

Etiology of decreased gastric nitric oxide in the critically ill. Keywords Mesh Terms:

KEYWORDS: Stomach

MESH TERMS: metabolism

Chemical & Substance for Abstract: Etiology of decreased gastric nitric oxide in the critically ill. Information

Substance Name: Nitric Oxide

Registry Number: 10102-43-9

Grant and Affiliation Information for Etiology of decreased gastric nitric oxide in the critically ill.

AFFILIATION: Department of Medicine, University of New Mexico, Albuquerque, NM 87131, USA. mboivin@salud.unm.edu

Country: Canada

AGENCY: United States NCRR

GRANT: 5MO1 RR00997

ACRONYM: RR

MEDLINETA: J Investig Med

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