Ethyl pyruvate: a novel anti-inflammatory agent.

Ethyl pyruvate: a novel anti-inflammatory agent. Research Abstract Details 

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Ethyl pyruvate: a novel anti-inflammatory agent. Abstract Text:

M P Fink,

Ethyl pyruvate (EP) is a simple derivative of the endogenous metabolite, pyruvic acid. Treatment with EP has been shown to improve survival and/or ameliorate organ dysfunction in a wide variety of preclinical models of critical illnesses, such as severe sepsis, acute respiratory distress syndrome, acute pancreatitis and stroke. EP was originally regarded as simply a way to administer pyruvate anion, whilst avoiding some of the problems associated with the instability of pyruvate in aqueous solutions. Increasingly, however, it is becoming apparent that certain pyruvate esters, including EP, have pharmacological effects, such as suppression of inflammation, that are quite distinct from those exerted by pyruvate anion. EP has been tested in human volunteers and shown to be safe at clinically relevant doses. It remains to be determined whether EP can be used successfully to treat human diseases.

Ethyl pyruvate: a novel anti-inflammatory agent. Publishing Authors By Initials

MP Fink,

For similar animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats research abstracts see: animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats research

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Ethyl pyruvate: a novel anti-inflammatory agent. Journal Published:

PUBLICATION TYPE: Review

Journal: Journal of internal medicine

VOLUME: 261

Page Numbers: 349-62

Journal Abbreviation: J. Intern. Med.

ISSN: 0954-6820

DAY: 3

MONTH: Apr

YEAR: 2007

Ethyl pyruvate: a novel anti-inflammatory agent. Information

Number of References: 88

LANGUAGE: eng

NlmUniqueID: 8904841

Ethyl pyruvate: a novel anti-inflammatory agent. Keywords Mesh Terms:

KEYWORDS: Rats

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: Ethyl pyruvate: a novel anti-inflammatory agent. Information

Substance Name: ethyl pyruvate

Registry Number: 617-35-6

Grant and Affiliation Information for Ethyl pyruvate: a novel anti-inflammatory agent.

AFFILIATION: Departments of Critical Care Medicine, Pharmacology and Surgery, University of Pittsburgh Medical School, Pittsburgh, PA 15261, USA. finkmp@ccm.upmc.edu

Country: England

AGENCY: United States NIGMS

GRANT: GM58484

ACRONYM: GM

MEDLINETA: J Intern Med

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