Ethanol-induced apoptosis and oxidative stress in hepatocytes.

Ethanol-induced apoptosis and oxidative stress in hepatocytes. Research Abstract Details 

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Ethanol-induced apoptosis and oxidative stress in hepatocytes. Abstract Text:

H Higuchi,I Kurose,S Kato,S Miura,H Ishii,

This short review focuses on ethanol-induced oxidative stress and hepatocyte apoptosis. Apoptosis is increasingly recognized as a fundamental biological process that impacts on an early development, maturation, and acquisition of disease states of multicellular organisms. Although the occurrence of apoptosis has been identified for many decades, relatively recent acceptance of this principle is evidenced by remarkable increases in special conferences and presentations on this topic as well as its rapidly expanding volume of scientific literature. Oxidative stress is well recognized to be a key step in the pathogenesis of ethanol-associated liver injury. Ethanol administration induces an increase in lipid peroxidation either by enhancing the production of oxygen reactive species and/or by decreasing the level of endogenous antioxidants. Studies in our laboratory using a confocal laser scanning microscopic system strongly suggest that agents which inhibit ethanol-induced oxidative stress effectively attenuate hepatocyte death, i.e., apoptosis and necrosis. In addition, our investigations demonstrated that inhibitors of intracellular antioxidants exaggerate ethanol-associated hepatocyte apoptosis. Although the detailed mechanism still remains unknown, it is conceivable that an oxidant-dependent mechanism is largely involved in the process for ethanol-induced hepatocyte apoptosis.

Ethanol-induced apoptosis and oxidative stress in hepatocytes. Publishing Authors By Initials

H Higuchi,I Kurose,S Kato,S Miura,H Ishii,

For similar inorganic chemicals: free radicals: reactive oxygen species research abstracts see: inorganic chemicals: free radicals: reactive oxygen species research

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Ethanol-induced apoptosis and oxidative stress in hepatocytes. Journal Published:

PUBLICATION TYPE: Review

Journal: Alcoholism, clinical and experimental research

VOLUME: 20

Page Numbers: 340A-346A

Journal Abbreviation: Alcohol. Clin. Exp. Res.

ISSN: 0145-6008

DAY: 22

MONTH: Dec

YEAR: 1996

Ethanol-induced apoptosis and oxidative stress in hepatocytes. Information

Number of References: 65

LANGUAGE: eng

NlmUniqueID: 7707242

Ethanol-induced apoptosis and oxidative stress in hepatocytes. Keywords Mesh Terms:

KEYWORDS: Reactive Oxygen Species

MESH TERMS: metabolism

Chemical & Substance for Abstract: Ethanol-induced apoptosis and oxidative stress in hepatocytes. Information

Substance Name: Ethanol

Registry Number: 64-17-5

Grant and Affiliation Information for Ethanol-induced apoptosis and oxidative stress in hepatocytes.

AFFILIATION: Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan.

Country: UNITED STATES

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MEDLINETA: Alcohol Clin Exp Res

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