Ethanol and acetaldehyde metabolism in cultured rat hepatocytes.

Ethanol and acetaldehyde metabolism in cultured rat hepatocytes. Research Abstract Details 

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Ethanol and acetaldehyde metabolism in cultured rat hepatocytes. Abstract Text:

In the present study, ethanol (Et-OH) and acetaldehyde (Ac-CHO) metabolism in primary cultured hepatocytes isolated from chronically alcohol-fed rats were analysed to elucidate the characteristics of the metabolism of Ac-CHO produced through the non-alcohol dehydrogenase (non-ADH) pathway. Dimethyl sulfoxide was added to the culture medium to prevent a decrease in P450 IIE1 activity. Ac-CHO formed in the culture medium was trapped by semicarbazide to prevent a reutilization of Ac-CHO by hepatocytes. The degradation rate of Ac-CHO in the liver was similar in alcohol and non-alcohol-treated rats. Therefore, the characteristic of the metabolism of Ac-CHO in the chronically alcohol-fed rats was not clarified in this study. The possibility that the Ac-CHO trapping by semicarbazide was only 70%, and that the remaining Ac-CHO was reutilized for oxidation in the hepatocytes, should be considered. Some method to trap Ac-CHO completely in the culture medium is needed to clarify the characteristics of Ac-CHO metabolism.

Ethanol and acetaldehyde metabolism in cultured rat hepatocytes. Publishing Authors By Initials

For similar organic chemicals: semicarbazides research abstracts see: organic chemicals: semicarbazides research

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Ethanol and acetaldehyde metabolism in cultured rat hepatocytes. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Alcohol and alcoholism (Oxford, Oxfordshire). Supp

VOLUME: 1A

Page Numbers: 3-10

Journal Abbreviation:

ISSN: 1358-6173

DAY: 26

MONTH: 02

YEAR: 1993

Ethanol and acetaldehyde metabolism in cultured rat hepatocytes. Information

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LANGUAGE: eng

NlmUniqueID: 8804836

Ethanol and acetaldehyde metabolism in cultured rat hepatocytes. Keywords Mesh Terms:

KEYWORDS: Semicarbazides

MESH TERMS: metabolism

Chemical & Substance for Abstract: Ethanol and acetaldehyde metabolism in cultured rat hepatocytes. Information

Substance Name: Aldehyde Dehydrogenase

Registry Number: EC 1.2.1.3

Grant and Affiliation Information for Ethanol and acetaldehyde metabolism in cultured rat hepatocytes.

AFFILIATION: Department of Internal Medicine, Kanazawa Medical University, Ishikawa, Japan.

Country: ENGLAND

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MEDLINETA: Alcohol Alcohol Suppl

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