[Estrogenic and androgenic effects of low dose raw water organics]

[Estrogenic and androgenic effects of low dose raw water organics] Research Abstract Details 

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[Estrogenic and androgenic effects of low dose raw water organics] Abstract Text:

Guo-zhou Zhang,Yu-jie Zhang,Xia Wang,Li-hong Yin,

OBJECTIVE: To study the estrogenic and (anti)androgenic effects caused by low-dose raw water organic compounds. METHODS: The organic compounds from raw water was concentrated with solid-phase extraction. Rodent 3-day Uterotrophic Assay and Hershberger assay, the assays recommended in EPA Tier 1 Screening Program for EDCs, were employed to investigate estrogenic and (anti) androgenic effects of these chemical mixture exposure. Doses equivalent to human daily intake were administered to laboratory animals. RESULTS: Low-dose effects of water organic compounds,which refer to levels of human daily water intake, did not show a statistical difference of weights of mouse uterus and rat sexual accessory glands(SAG) from the negative control in Uterotrophic Assay and Hershberger Assay, except the height of uterus epithelial in 4.0 L / 60 kg was significant difference with negative control. CONCLUSION: Based upon the water sample tested, it did not suggest that the low-dose raw water organic compounds exposure equivalent to people daily drinking water intake cause rodents (anti)androgenic in vivo effects, but it demonstrated a suspected estrogenic effect.

[Estrogenic and androgenic effects of low dose raw water organics] Publishing Authors By Initials

GZ Zhang,YJ Zhang,X Wang,LH Yin,

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[Estrogenic and androgenic effects of low dose raw water organics] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Wei sheng yan jiu = Journal of hygiene research

VOLUME: 35

Page Numbers: 171-4

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ISSN: 1000-8020

DAY: 8

MONTH: Mar

YEAR: 2006

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LANGUAGE: chi

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Grant and Affiliation Information for [Estrogenic and androgenic effects of low dose raw water organics]

AFFILIATION: Key Laboratory of the Public Health and Safety Ministry of Education Department of Environmental Health, School of Public Health, Fudan University, Shanghai 200032, China.

Country: China

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MEDLINETA: Wei Sheng Yan Jiu

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