Estrogen receptors in pancreatic tumors.

Estrogen receptors in pancreatic tumors. Research Abstract Details 

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Estrogen receptors in pancreatic tumors. Abstract Text:

Makoto Satake,Hirozumi Sawai,Vay Liang W Go,Katsusuke Satake,Howard A Reber,Oscar J Hines,Guido Eibl,

OBJECTIVES: Although a potential role for estrogen receptors (ER) in pancreatic tumors has been debated for many years, the importance of the receptors in these neoplasms remains unknown. Even the expression of the 2 ER isoforms, ER-alpha and ER-beta, in histological subtypes of pancreatic neoplasms is controversial. The aim of the present study was to systematically review the available literature about ER expression in pancreatic tumors and to discuss the potential importance of estrogen signaling in them. METHODS: We performed a comprehensive literature search and analyzed the results regarding ER expression in pancreatic tumors, with special emphasis on the specificity of the antibodies used for immunohistochemistry. RESULTS: Many articles have been published investigating the expression of ERs in pancreatic tumors, but the results are inconsistent. Moreover, most studies used antibodies that detected only ER-alpha, not ER-beta. Thus, the expression pattern of ER-beta in pancreatic neoplasm remains especially unclear. CONCLUSIONS: The lack of detailed studies evaluating the expression of both ER-alpha and ER-beta receptors using isoform-specific antibodies likely contributes to the inconsistency of published results concerning ER expression in pancreatic tumors. Available published evidence suggests that a thorough reexamination of the potential role of ERs in pancreatic neoplasms is warranted.

Estrogen receptors in pancreatic tumors. Publishing Authors By Initials

M Satake,H Sawai,VL Go,K Satake,HA Reber,OJ Hines,G Eibl,

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Estrogen receptors in pancreatic tumors. Journal Published:

PUBLICATION TYPE: Review

Journal: Pancreas

VOLUME: 33

Page Numbers: 119-27

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ISSN: 1536-4828

DAY: 3

MONTH: Aug

YEAR: 2006

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LANGUAGE: eng

NlmUniqueID: 8608542

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Grant and Affiliation Information for Estrogen receptors in pancreatic tumors.

AFFILIATION: Division of General Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-7330, USA.

Country: United States

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MEDLINETA: Pancreas

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