Estrogen Receptor-Negative Invasive Breast Cancer: Imaging Features of Tumors with and without Human Epidermal Growth Factor Receptor Type 2 Overexpression.

Estrogen Receptor-Negative Invasive Breast Cancer: Imaging Features of Tumors with and without Human Epidermal Growth Factor Receptor Type 2 Overexpression. Research Abstract Details 

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Estrogen Receptor-Negative Invasive Breast Cancer: Imaging Features of Tumors with and without Human Epidermal Growth Factor Receptor Type 2 Overexpression. Abstract Text:

Yingbing Wang,Debra M Ikeda,Balasubramanian Narasimhan,Teri A Longacre,Richard J Bleicher,Sunita Pal,Roger J Jackman,Stefanie S Jeffrey,Yingbing Wang,Debra M Ikeda,Balasubramanian Narasimhan,Teri A Longacre,Richard J Bleicher,Sunita Pal,Roger J Jackman,Stefanie S Jeffrey,

Purpose: To prospectively determine if estrogen receptor (ER)-negative human epidermal growth factor receptor type 2 (HER2)-positive and ER-negative HER2-negative breast cancers have distinguishing clinical and imaging features with use of retrospectively identified patients and tissue samples. Materials and Methods: This HIPAA-compliant study was institutional review board approved. Informed consent was obtained from living patients and waived for deceased patients. Mean patient age at diagnosis was 53 years (range, 31-84 years). Clinical history; histopathologic, mammographic, and breast sonographic findings; and HER2 status as determined with immunohistochemistry or fluorescent in situ hybridization were evaluated in 56 women with ER-negative breast cancer. Imaging appearances and clinicopathologic characteristics were correlated with tumor HER2 status. P < .05 indicated a significant difference. Results: Lesion margins on mammograms (P = .028) and sonograms (P = .023), calcifications on mammograms (P = .003), and clinical cancer stage at diagnosis (P = .029) were significantly associated with HER2 status. In contrast to ER-negative HER2-negative tumors, ER-negative HER2-positive tumors were more likely to have spiculated margins (56% vs 15%), be associated with calcifications (65% vs 21%), and be detected at a higher cancer stage (74% vs 57%). Conclusion: Biologic diversity of cancers may manifest in imaging characteristics, and, conversely, studying the range of imaging features of cancers may help refine current molecular phenotypes. Supplemental material: http://radiology.rsnajnls.org/cgi/content/full/2462070169/DC1 (c) RSNA, 2008.

Estrogen Receptor-Negative Invasive Breast Cancer: Imaging Features of Tumors with and without Human Epidermal Growth Factor Receptor Type 2 Overexpression. Publishing Authors By Initials

Y Wang,DM Ikeda,B Narasimhan,TA Longacre,RJ Bleicher,S Pal,RJ Jackman,SS Jeffrey,Y Wang,DM Ikeda,B Narasimhan,TA Longacre,RJ Bleicher,S Pal,RJ Jackman,SS Jeffrey,

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Estrogen Receptor-Negative Invasive Breast Cancer: Imaging Features of Tumors with and without Human Epidermal Growth Factor Receptor Type 2 Overexpression. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Radiology

VOLUME: 246

Page Numbers: 367-75

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ISSN: 1527-1315

DAY: 7

MONTH: 01

YEAR: 2008

Estrogen Receptor-Negative Invasive Breast Cancer: Imaging Features of Tumors with and without Human Epidermal Growth Factor Receptor Type 2 Overexpression. Information

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LANGUAGE: eng

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AFFILIATION: 1 Departments of Surgery, Radiology, Health Research and Policy, and Pathology, Stanford University School of Medicine, Medical School Lab Surge Bldg Room P214, 1201 Welch Rd, Stanford, CA 94305-5494.

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