Estrogen receptor beta, but not alpha, mediates estrogen's effect on cocaine-induced reinstatement of extinguished cocaine-seeking behavior in ovariectomized female rats.

Estrogen receptor beta, but not alpha, mediates estrogen's effect on cocaine-induced reinstatement of extinguished cocaine-seeking behavior in ovariectomized female rats. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Estrogen receptor beta, but not alpha, mediates estrogen's effect on cocaine-induced reinstatement of extinguished cocaine-seeking behavior in ovariectomized female rats. Abstract Text:

Erin B Larson,Marilyn E Carroll,

Preclinical and clinical studies indicate that females are more vulnerable to relapse than males, and the neurobiological effects of estrogen are thought to mediate, in part, the sex differences in cocaine-taking behavior. The goal of the present study was to investigate the involvement of estrogen receptor alpha (ERalpha) and beta (ERbeta) in estrogen-mediated increases in cocaine-induced reinstatement of extinguished cocaine-seeking behavior in ovariectomized (OVX) female rats. Rats were initially trained to self-administer cocaine (0.4 mg/kg/inf, i.v.) under a fixed-ratio 1 (FR 1) schedule of reinforcement during daily 2-h sessions. After a 10-day maintenance period, cocaine solutions were replaced with saline, and self-administration was extinguished over a 14-day period. OVX rats were then treated with either the mixed ERalpha/beta agonist estradiol benzoate (EB), the ERalpha-selective agonist, propyl-pyrazole-triol (PPT), the ERbeta-selective agonist, diarylpropionitrile (DPN), or a vehicle control (dimethyl sulfoxide, DMSO). Treatment lasted a total of 9 days, and during this time, rats were assessed for nonreinforced reinstatement of extinguished cocaine-seeking behavior after priming injections of saline or cocaine (5, 10, or 15 mg/kg, i.p.). OVX rats showed no differences in self-administration during maintenance or extinction. OVX rats treated with EB exhibited greater responding for cocaine during reinstatement compared to OVX+DMSO controls. Selective activation of ERbeta with DPN also increased cocaine-induced reinstatement responding, whereas selective activation of ERalpha with PPT did not affect cocaine-seeking behavior. These results indicate that estrogen influences the propensity for reinstatement of extinguished cocaine-seeking behavior, and that estrogen-mediated enhancement of cocaine-induced reinstatement responding involves the activation of ERbeta.

Estrogen receptor beta, but not alpha, mediates estrogen's effect on cocaine-induced reinstatement of extinguished cocaine-seeking behavior in ovariectomized female rats. Publishing Authors By Initials

EB Larson,ME Carroll,

For similar animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats: rats, wistar research abstracts see: animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats: rats, wistar research

PUBMED ID PMID:

MEDLINE DATE:

Estrogen receptor beta, but not alpha, mediates estrogen's effect on cocaine-induced reinstatement of extinguished cocaine-seeking behavior in ovariectomized female rats. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Neuropsychopharmacology : official publication of

VOLUME: 32

Page Numbers: 1334-45

Journal Abbreviation: Neuropsychopharmacology

ISSN: 0893-133X

DAY: 29

MONTH: 11

YEAR: 2006

Estrogen receptor beta, but not alpha, mediates estrogen's effect on cocaine-induced reinstatement of extinguished cocaine-seeking behavior in ovariectomized female rats. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8904907

Estrogen receptor beta, but not alpha, mediates estrogen's effect on cocaine-induced reinstatement of extinguished cocaine-seeking behavior in ovariectomized female rats. Keywords Mesh Terms:

KEYWORDS: Rats, Wistar

MESH TERMS: drug effects

Chemical & Substance for Abstract: Estrogen receptor beta, but not alpha, mediates estrogen's effect on cocaine-induced reinstatement of extinguished cocaine-seeking behavior in ovariectomized female rats. Information

Substance Name: Cocaine

Registry Number: 50-36-2

Grant and Affiliation Information for Estrogen receptor beta, but not alpha, mediates estrogen's effect on cocaine-induced reinstatement of extinguished cocaine-seeking behavior in ovariectomized female rats.

AFFILIATION: Department of Psychiatry, Graduate Program in Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA. larso323@umn.edu

Country: United States

AGENCY: United States NIDA

GRANT: R01 DA03240

ACRONYM: DA

MEDLINETA: Neuropsychopharmacology

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Estrogen receptor beta, but not alpha, mediates estrogen's effect on cocaine-induced reinstatement of extinguished cocaine-seeking behavior in ovariectomized female rats Related Publications

• A cognitive behavioral therapy for alcohol-dependent domestic violence offenders: an integrated substance abuse-domestic violence treatment approach (SADV).
• A field investigation of the effects of bovine viral diarrhea virus infection around the time of insemination on the reproductive performance of cattle.
• Acquisition of i.v. cocaine self-administration in adolescent and adult male rats selectively bred for high and low saccharin intake.
• Augmentation of intertransverse process lumbar fusion.
• Birth and a vision: lamaze childbirth education in kenya, East Africa.
• Chronic urinary infections in infants and children.
• Comparing onset of antidepressant action using a repeated measures approach and a traditional assessment schedule.
• Education predicts quality of life among men with prostate cancer cared for in the Department of Veterans Affairs: a longitudinal quality of life analysis from CaPSURE.
• Effect of monensin, energy level, and cow body condition on pregnancy rate in nonlactating beef cows.
• Effects of Exercise Training on Blood Pressure and Renin-Angiotensin System Activation in Overweight Postmenopausal Women in the Dose-Response to Exercise in Women (DREW) Study: 1931: Board #1 May 31 3:30 PM - 5:00 PM.
• Enhanced growth of myelodysplastic colonies in hypoxic conditions.
• Estrogen receptor beta, but not alpha, mediates estrogen's effect on cocaine-induced reinstatement of extinguished cocaine-seeking behavior in ovariectomized female rats.
• Follicular exclusion of autoreactive B cells requires FcgammaRIIb.
• Gadolinium-enhanced off-resonance contrast angiography.
• Health-related quality of life for men with prostate cancer and diabetes: a longitudinal analysis from CaPSURE.
• Impulsivity (delay discounting) for food and cocaine in male and female rats selectively bred for high and low saccharin intake.
• Induction and repair of zinc-finger nuclease-targeted double-strand breaks in Caenorhabditis elegans somatic cells.
• Integrating marriage education into perinatal education.
• Multiinstitutional validation of the UCSF cancer of the prostate risk assessment for prediction of recurrence after radical prostatectomy.
• Multiple initial culture conditions enhance the establishment of cell lines from primary ovarian cancer specimens.
• Natural antibody mediated innate autoimmune response.
• Postnatal development of carotid body glomus cell response to hypoxia.
• Quality of life for men receiving a second treatment for prostate cancer.
• Recovery of balance and gait function 18 months post-spinal shock: a single subject study design: 1648: board #138 may 30 2:00 PM - 3:30 PM.
• Recovery of urinary continence following radical prostatectomy: the impact of prostate volume--analysis of data from the CaPSURE Database.
• Reduced incidence of bony metastasis at initial prostate cancer diagnosis: data from CaPSURE.
• Role of California (Callipepla californica) and Gambel's (Callipepla gambelii) quail in the ecology of mosquito-borne encephalitis viruses in California, USA.
• Social stimuli enhance phencyclidine (PCP) self-administration in rhesus monkeys.
• Temporal expression analysis of the Borrelia burgdorferi paralogous gene family 54 genes BBA64, BBA65, and BBA66 during persistent infection in mice.
• The UBX-regulated network in the haltere imaginal disc of D. melanogaster.