Estrogen Modulates Bone Marrow-Derived DCs in SLE Murine Model-(NZB x NZW) F1 Female Mice.

Estrogen Modulates Bone Marrow-Derived DCs in SLE Murine Model-(NZB x NZW) F1 Female Mice. Research Abstract Details 

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Estrogen Modulates Bone Marrow-Derived DCs in SLE Murine Model-(NZB x NZW) F1 Female Mice. Abstract Text:

Bo Jiang,Lingyun Sun,Sha Hao,Xiaoxi Li,Yixin Xu,Yayi Hou,Bo Jiang,Lingyun Sun,Sha Hao,Xiaoxi Li,Yixin Xu,Yayi Hou,

Dendritic cells (DCs) in the patient and animal models of systemic lupus erythematosus (SLE) are abnormal, but the detailed mechanism is unclear. Estrogen can modulate DCs in biological condition and estrogen consentration is related to the onset and development of SLE. So the control of estrogen on DCs might lead to the disorder of DCs. To prove the hypothesis, we detected the effects of 17beta-estradiol (E2) on bone marrow (BM)-derived DCs in SLE murine model-(NZB x NZW) F1 (NZB/w F1) female mice before and after the disease onset. We found that E2 mainly enhanced the expression of surface molecule CD40, MHCII and the stimulation activity of immature DCs, but weakened the activity of mature DCs. E2 decreased the production of cytokines IL-6, IL-10, IL-12 and TNFalpha of DCs in young mice, but increased them in old mice. Tamoxifen could antagonize the E2 effect. E2 changed the expression of estrogen receptor-alpha (ERalpha) in DCs. The level of ERalpha in DCs of various old mice and the differentiation states varied. The results suggest that E2 can modulate the functions of BM-derived DCs in SLE pathology. The modulation is achieved by binding ER. The effects of E2 on DCs are different depending on the progression of SLE and cell differentiation status. This might be due to the difference of ER expression.

Estrogen Modulates Bone Marrow-Derived DCs in SLE Murine Model-(NZB x NZW) F1 Female Mice. Publishing Authors By Initials

B Jiang,L Sun,S Hao,X Li,Y Xu,Y Hou,B Jiang,L Sun,S Hao,X Li,Y Xu,Y Hou,

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Estrogen Modulates Bone Marrow-Derived DCs in SLE Murine Model-(NZB x NZW) F1 Female Mice. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Immunological investigations

VOLUME: 37

Page Numbers: 227-43

Journal Abbreviation: Immunol. Invest.

ISSN: 1532-4311

DAY: 4

MONTH: 04

YEAR: 2008

Estrogen Modulates Bone Marrow-Derived DCs in SLE Murine Model-(NZB x NZW) F1 Female Mice. Information

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LANGUAGE: eng

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AFFILIATION: Immunology and Reproductive Biology Lab, Medical School & State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, P. R. China.

Country: United States

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MEDLINETA: Immunol Invest

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