Estradiol increases proteinuria and angiotensin II type 1 receptor in kidneys of rats receiving L-NAME and angiotensin II.

Estradiol increases proteinuria and angiotensin II type 1 receptor in kidneys of rats receiving L-NAME and angiotensin II. Research Abstract Details 

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Estradiol increases proteinuria and angiotensin II type 1 receptor in kidneys of rats receiving L-NAME and angiotensin II. Abstract Text:

E M Oestreicher,C Guo,E W Seely,T Kikuchi,D Martinez-Vasquez,L Jonasson,T Yao,D Burr,S Mayoral,W Roubsanthisuk,V Ricchiuti,G K Adler,

Prospective, placebo-controlled clinical trials suggest that estrogen may have adverse effects on the vascular system in women. The goal of this study was to determine if 17beta-estradiol (E2) would have adverse effects on the renovasculature in a rat model of renal injury characterized by low nitric oxide (NO) and high angiotensin II (AngII). We studied female Wistar rats that were sham-operated (sham), ovariectomized (OVX), or ovariectomized and replaced with E2 (OVX/E2). All rats were maintained on a high salt diet and renovascular injury was caused by treating rats with an inhibitor of NO synthase, N(omega)-nitro-L-arginine-methyl-ester (L-NAME), for 14 days, plus AngII on days 11 through 14. L-NAME/AngII treatment, as compared to placebo, caused proteinuria, glomerular injury, and fibrinoid necrosis of renal arterioles in sham-operated rats. Ovariectomy reduced L-NAME/AngII-induced renal damage, whereas E2 treatment increased L-NAME/AngII-induced damage in OVX rats. In rats treated with L-NAME/AngII, levels of AngII type 1 receptor (AT(1)R) protein were higher in the renal cortex of sham and OVX/E2 rats than in OVX rats. AT(1)R protein correlated with renal injury. E2 treatment also increased expression of AT(1)R mRNA. Thus, under conditions of low NO and high AngII, E2 exacerbated renal injury. E2-mediated increases in renal cortical AT(1)R expression may represent a novel mechanism for the adverse renovascular effects of estrogen.

Estradiol increases proteinuria and angiotensin II type 1 receptor in kidneys of rats receiving L-NAME and angiotensin II. Publishing Authors By Initials

EM Oestreicher,C Guo,EW Seely,T Kikuchi,D Martinez-Vasquez,L Jonasson,T Yao,D Burr,S Mayoral,W Roubsanthisuk,V Ricchiuti,GK Adler,

For similar chemical actions and uses: pharmacologic actions: therapeutic uses: cardiovascular agents: vasoconstrictor agents research abstracts see: chemical actions and uses: pharmacologic actions: therapeutic uses: cardiovascular agents: vasoconstrictor agents research

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Estradiol increases proteinuria and angiotensin II type 1 receptor in kidneys of rats receiving L-NAME and angiotensin II. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Kidney international

VOLUME: 70

Page Numbers: 1759-68

Journal Abbreviation: Kidney Int.

ISSN: 0085-2538

DAY: 4

MONTH: 10

YEAR: 2006

Estradiol increases proteinuria and angiotensin II type 1 receptor in kidneys of rats receiving L-NAME and angiotensin II. Information

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LANGUAGE: eng

NlmUniqueID: 323470

Estradiol increases proteinuria and angiotensin II type 1 receptor in kidneys of rats receiving L-NAME and angiotensin II. Keywords Mesh Terms:

KEYWORDS: Vasoconstrictor Agents

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Estradiol increases proteinuria and angiotensin II type 1 receptor in kidneys of rats receiving L-NAME and angiotensin II. Information

Substance Name: NG-Nitroarginine Methyl Ester

Registry Number: 50903-99-6

Grant and Affiliation Information for Estradiol increases proteinuria and angiotensin II type 1 receptor in kidneys of rats receiving L-NAME and angiotensin II.

AFFILIATION: Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: HL-63423

ACRONYM: HL

MEDLINETA: Kidney Int

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