Estimation of cholesterol solubilization by a mixed micelle binding model in aqueous tauroursodeoxycholate:lecithin:cholesterol solutions.

Estimation of cholesterol solubilization by a mixed micelle binding model in aqueous tauroursodeoxycholate:lecithin:cholesterol solutions. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Estimation of cholesterol solubilization by a mixed micelle binding model in aqueous tauroursodeoxycholate:lecithin:cholesterol solutions. Abstract Text:

William I Higuchi,Chinn-Shin Tzeng,Shyh-Jye Chang,Huey-Jenn Chiang,Chen-Lun Liu,William I Higuchi,Chinn-Shin Tzeng,Shyh-Jye Chang,Huey-Jenn Chiang,Chen-Lun Liu,William I Higuchi,Chinn-Shin Tzeng,Shyh-Jye Chang,Huey-Jenn Chiang,Chen-Lun Liu,

In order to interpret the clinical efficacy of conjugated ursodeoxycholate (UDC) in cholesterol (Ch) gallstone patients, the Ch solubilization in mixed micelles in 40:40:32 mM tauroursodeoxycholate (TUDC):taurochenodeoxycholate (TCDC):lecithin (L) and 80:32 mM TUDC:L systems was estimated by using a model of Ch binding to mixed micelles. The Ch solubilization limit in mixed TUDC:L micelles was found to be higher than that in mixed TUDC:TCDC:L micelles. In the 80:32 mM TUDC:L system, the dissolution of the Ch pellet decreased after vesicles (liposomes) formed on the surface of the Ch pellet whereas the dissolution of microcrystalline Ch was rapid before and after vesicle formation in the solution, indicating that the total surface area of solid Ch exposed to the solution may be another important factor in inducing the dissolution of Ch gallstones. These phenomena suggest that although vesicles, occasionally formed in the bile of patients under the therapy of conjugated UDC, make a contribution to the solubilization of Ch gallstones, the model of Ch binding to mixed TUDC:L micelles can be used to estimate Ch solubility in TUDC:L system.

Estimation of cholesterol solubilization by a mixed micelle binding model in aqueous tauroursodeoxycholate:lecithin:cholesterol solutions. Publishing Authors By Initials

WI Higuchi,CS Tzeng,SJ Chang,HJ Chiang,CL Liu,WI Higuchi,CS Tzeng,SJ Chang,HJ Chiang,CL Liu,WI Higuchi,CS Tzeng,SJ Chang,HJ Chiang,CL Liu,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Estimation of cholesterol solubilization by a mixed micelle binding model in aqueous tauroursodeoxycholate:lecithin:cholesterol solutions. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of pharmaceutical sciences

VOLUME: 97

Page Numbers: 340-9

Journal Abbreviation:

ISSN: 0022-3549

DAY: 6

MONTH: Jan

YEAR: 2008

Estimation of cholesterol solubilization by a mixed micelle binding model in aqueous tauroursodeoxycholate:lecithin:cholesterol solutions. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985195

Estimation of cholesterol solubilization by a mixed micelle binding model in aqueous tauroursodeoxycholate:lecithin:cholesterol solutions. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Estimation of cholesterol solubilization by a mixed micelle binding model in aqueous tauroursodeoxycholate:lecithin:cholesterol solutions. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Estimation of cholesterol solubilization by a mixed micelle binding model in aqueous tauroursodeoxycholate:lecithin:cholesterol solutions.

AFFILIATION: Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT 84112, USA.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Pharm Sci

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Estimation of cholesterol solubilization by a mixed micelle binding model in aqueous tauroursodeoxycholate:lecithin:cholesterol solutions Related Publications

• Altered mucin gene expression in stone-containing intrahepatic bile ducts and cholangiocarcinomas.
• Clinical study on labor pain relief using the combined spinal-epidural analgesia and inhaling nitrous oxide.
• Detection of cariogenic Streptococcus mutans by quantitative polymerase chain reaction.
• Diagnosis and treatment of primary gastric non-Hodgkin's lymphoma: analysis of 157 patients.
• Experimental study on the effect of cyclosporine A drug delivery system implanted in anterior chamber on high-risk corneal graft rejection.
• Inhibitory effects of RRR-alpha-tocopheryl succinate on benzo(a)pyrene (B(a)P)-induced forestomach carcinogenesis in female mice.
• Mechanism and treatments of regression and haze after photorefractive keratectomy.
• Reconstruction and transplantation of composite skin containing keratinocytes and fibroblasts.
• Studies of WT1 gene expression in leukemia patients.
• [A case report of primary sclerosing cholangiolitis with Budd-Chiari syndrome]
• [A study on the epidemiological characteristics and the preventive measures of rabies in Shanghai]
• [Clinical and pathological characteristics of primary biliary cirrhosis]
• [Clinical results of transmyocardial laser revascularization for 77 patients with coronary artery disease]
• [Difference in action sites between mecamylamine and hexamethonium on nicotinic receptors of sympathetic neurons]
• [Differences of nitric oxide synthase expression and activity between splanchnic arterial and venous vessels of cirrhotic rats]
• [Effects of recombinant human bone morphogenic protein-2 and hyaluronic acid on invasion of brain glioma in vivo]
• [Improved three-dimension reconstruction of serial frozen tissue sections of the temporal bone of guinea pigs]
• [Measurement of anti-acetaldehyde protein adduct IgA, IgG, IgM antibody titers in the sera of human alcoholics]
• [Recent research advances in oxidized high density lipoproteins]
• [Regulation of c-myc expression in leukemic cell line Meg-01 by the death domain of Fas gene]
• [Relationship between the proliferative activity of cancer cells and microvessel density in portal vein thrombosis and transfer of hepatocellular carcinoma]
• [Studies on cell transformation and cell cycle in human embryo lungs induced by nickel compounds]
• [Study on the epidemiological feature and control measure for rabies from 1990 to 2000 in Jiangsu province]
• [Surgical treatment of epispadias]
• [The application of colour Doppler and ultrasonography the grading and staging of chronic hepatitis with and without liver cirrhosis]
• [The determination of anions of very weak acids by incompletely suppressed conductometric detection]
• [The experimental study on the activity of rhBMP-2, coral and collagen composites inducing intramuscle bone]
• [The expression of P16, P21(WAF1/CIP1) and Cyclin D1 proteins in skin of patients with arseniasis caused by coal-burning and their significance]
• [The sinus node itself also plays a role in heart rate slowing down during postnatal development]
• [The ultrastructure of bone morphogenetic protein 2 gene transfected human periodontal ligament fibroblasts]