Estimating p-values in small microarray experiments.

Estimating p-values in small microarray experiments. Research Abstract Details 

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Estimating p-values in small microarray experiments. Abstract Text:

Hyuna Yang,Gary Churchill,

MOTIVATION: Microarray data typically have small numbers of observations per gene, which can result in low power for statistical tests. Test statistics that borrow information from data across all of the genes can improve power, but these statistics have non-standard distributions, and their significance must be assessed using permutation analysis. When sample sizes are small, the number of distinct permutations can be severely limited, and pooling the permutation-derived test statistics across all genes has been proposed. However, the null distribution of the test statistics under permutation is not the same for equally and differentially expressed genes. This can have a negative impact on both p-value estimation and the power of information borrowing statistics. RESULTS: We investigate permutation based methods for estimating p-values. One of methods that uses pooling from a selected subset of the data are shown to have the correct type I error rate and to provide accurate estimates of the false discovery rate (FDR). We provide guidelines to select an appropriate subset. We also demonstrate that information borrowing statistics have substantially increased power compared to the t-test in small experiments.

Estimating p-values in small microarray experiments. Publishing Authors By Initials

H Yang,G Churchill,

For similar investigative techniques: epidemiologic methods: statistics as topic: sensitivity and specificity research abstracts see: investigative techniques: epidemiologic methods: statistics as topic: sensitivity and specificity research

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Estimating p-values in small microarray experiments. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Bioinformatics (Oxford, England)

VOLUME: 23

Page Numbers: 38-43

Journal Abbreviation: Bioinformatics

ISSN: 1460-2059

DAY: 30

MONTH: 10

YEAR: 2006

Estimating p-values in small microarray experiments. Information

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LANGUAGE: eng

NlmUniqueID: 9808944

Estimating p-values in small microarray experiments. Keywords Mesh Terms:

KEYWORDS: Sensitivity and Specificity

MESH TERMS: methods

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Grant and Affiliation Information for Estimating p-values in small microarray experiments.

AFFILIATION: The Jackson Laboratory, Bar Harbor, ME 04609, USA.

Country: England

AGENCY: United States NCI

GRANT: CA88327

ACRONYM: CA

MEDLINETA: Bioinformatics

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