Estimated glomerular filtration rate in sickle cell anemia is associated with polymorphisms of bone morphogenetic protein receptor 1B.

Estimated glomerular filtration rate in sickle cell anemia is associated with polymorphisms of bone morphogenetic protein receptor 1B. Research Abstract Details 

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Estimated glomerular filtration rate in sickle cell anemia is associated with polymorphisms of bone morphogenetic protein receptor 1B. Abstract Text:

Vikki G Nolan,Qianli Ma,Herbert T Cohen,Adeboye Adewoye,Anne C Rybicki,Clinton Baldwin,Rhea N Mahabir,Erica P Homan,Diego F Wyszynski,Mary E Fabry,Ronald L Nagel,Lindsay A Farrer,Martin H Steinberg,

Renal disease is common in sickle cell anemia. In this exploratory work, we used data from a longitudinal study of the natural history of sickle cell disease to examine the hypothesis that polymorphisms (SNPs) in selected candidate genes are associated with glomerular filtration rate (GFR). DNA samples and clinical and laboratory data were available for 1,140 patients with sickle cell anemia. GFR was estimated using the Cockcroft-Gault and Schwartz formulas for adults and children, respectively. We examined approximately 175 haplotype tagging (ht) SNPs in about 70 genes of the TGFbeta/BMP pathway for their association with GFR using linear regression. Four SNPs in BMPR1B, a bone morphogenetic protein (BMP) receptor gene, yielded statistically significant associations (P values ranging from 0.015 to 0.046). Three haplotypes in this gene were also associated with GFR. The TGF-beta/BMP pathway has been associated with the development of diabetic nephropathy, which has some features in common with sickle cell nephropathy. Our results suggest that, as with other subphenotypes of sickle cell disease, renal function may be genetically modulated.

Estimated glomerular filtration rate in sickle cell anemia is associated with polymorphisms of bone morphogenetic protein receptor 1B. Publishing Authors By Initials

VG Nolan,Q Ma,HT Cohen,A Adewoye,AC Rybicki,C Baldwin,RN Mahabir,EP Homan,DF Wyszynski,ME Fabry,RL Nagel,LA Farrer,MH Steinberg,

For similar genetic phenomena: variation (genetics): polymorphism, genetic: polymorphism, single nucleotide research abstracts see: genetic phenomena: variation (genetics): polymorphism, genetic: polymorphism, single nucleotide research

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Estimated glomerular filtration rate in sickle cell anemia is associated with polymorphisms of bone morphogenetic protein receptor 1B. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: American journal of hematology

VOLUME: 82

Page Numbers: 179-84

Journal Abbreviation: Am. J. Hematol.

ISSN: 0361-8609

DAY: 3

MONTH: Mar

YEAR: 2007

Estimated glomerular filtration rate in sickle cell anemia is associated with polymorphisms of bone morphogenetic protein receptor 1B. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7610369

Estimated glomerular filtration rate in sickle cell anemia is associated with polymorphisms of bone morphogenetic protein receptor 1B. Keywords Mesh Terms:

KEYWORDS: Polymorphism, Single Nucleotide

MESH TERMS: genetics

Chemical & Substance for Abstract: Estimated glomerular filtration rate in sickle cell anemia is associated with polymorphisms of bone morphogenetic protein receptor 1B. Information

Substance Name: Bone Morphogenetic Protein Receptors, Ty

Registry Number: EC 2.7.1.37

Grant and Affiliation Information for Estimated glomerular filtration rate in sickle cell anemia is associated with polymorphisms of bone morphogenetic protein receptor 1B.

AFFILIATION: Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: T32 HL007501

ACRONYM: HL

MEDLINETA: Am J Hematol

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