Establishment of novel human dedifferentiated chondrosarcoma cell line with osteoblastic differentiation.

Establishment of novel human dedifferentiated chondrosarcoma cell line with osteoblastic differentiation. Research Abstract Details 

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Establishment of novel human dedifferentiated chondrosarcoma cell line with osteoblastic differentiation. Abstract Text:

Naoko Kudo,Akira Ogose,Tetsuo Hotta,Hiroyuki Kawashima,Wenguang Gu,Hajime Umezu,Tsuyoshi Toyama,Naoto Endo,Naoko Kudo,Akira Ogose,Tetsuo Hotta,Hiroyuki Kawashima,Wenguang Gu,Hajime Umezu,Tsuyoshi Toyama,Naoto Endo,Naoko Kudo,Akira Ogose,Tetsuo Hotta,Hiroyuki Kawashima,Wenguang Gu,Hajime Umezu,Tsuyoshi Toyama,Naoto Endo,

Dedifferentiated chondrosarcoma is a rare, highly malignant variant of chondrosarcoma in which a high-grade sarcoma coexists with a low-grade chondroid tumor. We herein review a case of dedifferentiated chondrosarcoma with an osteosarcoma omit component that occurred in the distal femur of a 38-year-old man. We established the cell line (NDCS-1) from a pleural effusion of the metastatic lung tumor. The cell line was characterized by a the G-banded karyotype, polymerase chain reaction (PCR) single-strand conformation polymorphism analysis, spectral karyotyping, and reverse transcriptase PCR (RT-PCR). The tumor exhibited complex karyotypes and a high frequency of chromosomal amplication with p53 mutation. This tumor revealed an osteoblastic and chondroblastic character in vitro and in severe combined immunodeficiency mice. The expression and phosphorylation of platelet-derived growth factor receptor-beta, which seemed to play a major role in the malignant phenotype of chondrosarcoma, was confirmed by RT-PCR and Western blotting. To our knowledge, this is the first report of the establishment of a human dedifferentiated chondrosarcoma.

Establishment of novel human dedifferentiated chondrosarcoma cell line with osteoblastic differentiation. Publishing Authors By Initials

N Kudo,A Ogose,T Hotta,H Kawashima,W Gu,H Umezu,T Toyama,N Endo,N Kudo,A Ogose,T Hotta,H Kawashima,W Gu,H Umezu,T Toyama,N Endo,N Kudo,A Ogose,T Hotta,H Kawashima,W Gu,H Umezu,T Toyama,N Endo,

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Establishment of novel human dedifferentiated chondrosarcoma cell line with osteoblastic differentiation. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Virchows Archiv : an international journal of path

VOLUME: 451

Page Numbers: 691-9

Journal Abbreviation: Virchows Arch.

ISSN: 0945-6317

DAY: 26

MONTH: 07

YEAR: 2007

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LANGUAGE: eng

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AFFILIATION: Division of Orthopaedic Surgery,Department of Regenerative Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, 757-1 Asahimachi-dori Ichiban-cho, Niigata City, Niigata, 951-8510, Japan, aogose@med.niigata-u.ac.jp.

Country: Germany

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MEDLINETA: Virchows Arch

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