Essiac and Flor-Essence herbal tonics stimulate the in vitro growth of human breast cancer cells.

Essiac and Flor-Essence herbal tonics stimulate the in vitro growth of human breast cancer cells. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Essiac and Flor-Essence herbal tonics stimulate the in vitro growth of human breast cancer cells. Abstract Text:

Kristen S Kulp,Jennifer L Montgomery,David O Nelson,Beth Cutter,E Ray Latham,David L Shattuck,Diane M Klotz,L Michelle Bennett,

BACKGROUND: People diagnosed with cancer often self-administer complementary and alternative medicines (CAMs) to supplement their conventional treatments, improve health, or prevent recurrence. Flor-Essence and Essiac Herbal Tonics are commercially available complex mixtures of herbal extracts sold as dietary supplements and used by cancer patients based on anecdotal evidence that they can treat or prevent disease. In this study, we evaluated Flor-Essence and Essiac for their effects on the growth of human tumor cells in culture. METHODS: The effect of Flor-Essence and Essiac((R)) herbal tonics on cell proliferation was tested in MCF-7, MDA-MB-436, MDA-MB-231, and T47D cancer cells isolated from human breast tumors. Estrogen receptor (ER) dependent activation of a luciferase reporter construct was tested in MCF-7 cells. Specific binding to the ER was tested using an ICI 182,780 competition assay. RESULTS: Flor-Essence and Essiac herbal tonics at 1%, 2%, 4% and 8% stimulated cell proliferation relative to untreated controls in both estrogen receptor positive (MCF-7 and T47D) and estrogen receptor negative (MDA-MB-231 and MDA-MB-436) cell lines. Exposure to the tonics also produced a dose-dependent increase in ER dependent luciferase activity in MCF-7 cells. A 10(-7) M concentration of ICI 182,780 inhibited the induction of ER dependent luciferase activity by Flor-Essence and Essiac, but did not affect cell proliferation. CONCLUSION: Flor-Essence and Essiac Herbal Tonics can stimulate the growth of human breast cancer cells through ER mediated as well as ER independent mechanisms of action.

Essiac and Flor-Essence herbal tonics stimulate the in vitro growth of human breast cancer cells. Publishing Authors By Initials

KS Kulp,JL Montgomery,DO Nelson,B Cutter,ER Latham,DL Shattuck,DM Klotz,LM Bennett,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Essiac and Flor-Essence herbal tonics stimulate the in vitro growth of human breast cancer cells. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Breast cancer research and treatment

VOLUME: 98

Page Numbers: 249-59

Journal Abbreviation:

ISSN: 0167-6806

DAY: 16

MONTH: 03

YEAR: 2006

Essiac and Flor-Essence herbal tonics stimulate the in vitro growth of human breast cancer cells. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8111104

Essiac and Flor-Essence herbal tonics stimulate the in vitro growth of human breast cancer cells. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Essiac and Flor-Essence herbal tonics stimulate the in vitro growth of human breast cancer cells. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Essiac and Flor-Essence herbal tonics stimulate the in vitro growth of human breast cancer cells.

AFFILIATION: Biosciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA. Kulp2@llnl.gov

Country: Netherlands

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Breast Cancer Res Treat

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Essiac and Flor-Essence herbal tonics stimulate the in vitro growth of human breast cancer cells Related Publications

• Activation of platelet alphaIIbbeta3 by an exogenous peptide corresponding to the transmembrane domain of alphaIIb.
• Body mass index in older persons is associated with Alzheimer disease pathology.
• Change in motor function and risk of mortality in older persons.
• Chronic psychological distress and risk of Alzheimer's disease in old age.
• Cognitive decline in old age: separating retest effects from the effects of growing older.
• Diabetes is related to cerebral infarction but not to AD pathology in older persons.
• Diabetes mellitus, dementia, and cognitive function in older persons.
• Discriminating inhalational anthrax from community-acquired pneumonia using chest radiograph findings and a clinical algorithm.
• Effects of aquatic exercise on flexibility, strength and aerobic fitness in adults with osteoarthritis of the hip or knee.
• Elder abuse.
• Essiac and Flor-Essence herbal tonics stimulate the in vitro growth of human breast cancer cells.
• Experimental evidence for a metallohydrolase mechanism in which the nucleophile is not delivered by a metal ion: EPR spectrokinetic and structural studies of aminopeptidase from Vibrio proteolyticus.
• Genetic and environmental factors associated with incidence of infectious bovine keratoconjunctivitis in preweaned beef calves.
• Harm avoidance and disability in old age.
• Imaging oxygen pressure in the rodent retina by phosphorescence lifetime.
• In cis autosomal dominant mutation of Senataxin associated with tremor/ataxia syndrome.
• Isoform-specific effects of the beta2 subunit on voltage-gated sodium channel gating.
• Loneliness and risk of Alzheimer disease.
• Memory complaints are related to Alzheimer disease pathology in older persons.
• Memory for facial expressions: the power of a smile.
• Motor dysfunction in mild cognitive impairment and the risk of incident Alzheimer disease.
• Personality and incident disability in older persons.
• Physical activity and motor decline in older persons.
• Physical activity is associated with incident disability in community-based older persons.
• Plant genome values: how much do we know?
• Postmortem indices linking risk factors to cognition: results from the Religious Order Study and the Memory and Aging Project.
• Quantitative determination of uracil residues in Escherichia coli DNA: Contribution of ung, dug, and dut genes to uracil avoidance.
• Serotonin facilitates a persistent calcium current in motoneurons of rats with and without chronic spinal cord injury.
• The GLH proteins, Caenorhabditis elegans P granule components, associate with CSN-5 and KGB-1, proteins necessary for fertility, and with ZYX-1, a predicted cytoskeletal protein.
• Unusual skin and testicular lesions in a patient with CMML.