Essential roles of carbohydrate signals in development, immune response and tissue functions, as revealed by gene targeting.

Essential roles of carbohydrate signals in development, immune response and tissue functions, as revealed by gene targeting. Research Abstract Details 

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Essential roles of carbohydrate signals in development, immune response and tissue functions, as revealed by gene targeting. Abstract Text:

T Muramatsu,

Knockout mice lacking glycosyltransferases or sulfotransferases provide unequivocal evidence that the carbohydrate moieties of glycoproteins, glycolipids, and proteoglycans play essential roles in various biological phenomena such as development, the immune response, and tissue functions. Examples of abnormalities of null mutants include arrest of embryogenesis due to deletion of N-acetylglucosaminyltransferase I or glucosylceramide synthase, failure of kidney formation in heparan sulfate 2-O-sulfotransferase deficiency, suppressed antibody production in alpha-2, 6-sialyltransferase deficiency, male sterility in GM2/GD2 synthase deficiency, and abnormalities in the function and stability of myelin in galactosylceramide deficiency.

Essential roles of carbohydrate signals in development, immune response and tissue functions, as revealed by gene targeting. Publishing Authors By Initials

T Muramatsu,

For similar enzymes and coenzymes: enzymes: transferases: sulfur group transferases: sulfotransferases research abstracts see: enzymes and coenzymes: enzymes: transferases: sulfur group transferases: sulfotransferases research

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Essential roles of carbohydrate signals in development, immune response and tissue functions, as revealed by gene targeting. Journal Published:

PUBLICATION TYPE: Review

Journal: Journal of biochemistry

VOLUME: 127

Page Numbers: 171-6

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Feb

YEAR: 2000

Essential roles of carbohydrate signals in development, immune response and tissue functions, as revealed by gene targeting. Information

Number of References: 43

LANGUAGE: eng

NlmUniqueID: 376600

Essential roles of carbohydrate signals in development, immune response and tissue functions, as revealed by gene targeting. Keywords Mesh Terms:

KEYWORDS: Sulfotransferases

MESH TERMS: metabolism

Chemical & Substance for Abstract: Essential roles of carbohydrate signals in development, immune response and tissue functions, as revealed by gene targeting. Information

Substance Name: heparan-sulfate 2-sulfotransferase

Registry Number: EC 2.8.2.-

Grant and Affiliation Information for Essential roles of carbohydrate signals in development, immune response and tissue functions, as revealed by gene targeting.

AFFILIATION: Department of Biochemistry, Nagoya University School of Medicine, Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan. tmurama@tsuru.med. nagoya-u.ac.jp

Country: JAPAN

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MEDLINETA: J Biochem

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