Essential role of the TNF-TNFR2 cognate interaction in mouse dendritic cell-natural killer cell crosstalk.

Essential role of the TNF-TNFR2 cognate interaction in mouse dendritic cell-natural killer cell crosstalk. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Essential role of the TNF-TNFR2 cognate interaction in mouse dendritic cell-natural killer cell crosstalk. Abstract Text:

Jun Xu,Ayan K Chakrabarti,Jennifer L Tan,Lisheng Ge,Andrea Gambotto,Nikola L Vujanovic,

Dendritic cells (DCs) and natural killer (NK) cells are essential components of the innate immune system and have a central role in initiation and regulation of adaptive immune responses. During the early critical immune activities, DCs and NK cells interact and reciprocally regulate each other via cell-cell contact. The molecular mediators of the DC-NK-cell crosstalk are largely undefined. In the present study, we show in mice that DC stimulation of NK-cell IFN-gamma secretion requires DC membrane-bound but not secreted products; is increased by augmenting the expression of DC transmembrane tumor necrosis factor (tmTNF) and NK-cell transmembrane TNF receptor type 2 (tmTNFR2); is inhibited by blocking TNF or TNFR2 but not TNFR1; is impaired by knocking out DC Tnf or NK-cell Tnfr2 but not DC Tnfr1 or Tnfr2 and NK-cell Tnf or Tnfr1; and is restored in TNF-deficient DCs by reconstituting tmTNF, but cannot be mimicked by soluble TNF. We also demonstrate that DC TNF and NK-cell TNFR2 are required for DC-mediated NK-cell proliferation and amplification of cytotoxic activity. These novel findings provide the first evidence that DC-NK-cell crosstalk mediates enhancement of NK-cell functions via triggering NK-cell tmTNFR2 by DC tmTNF.

Essential role of the TNF-TNFR2 cognate interaction in mouse dendritic cell-natural killer cell crosstalk. Publishing Authors By Initials

J Xu,AK Chakrabarti,JL Tan,L Ge,A Gambotto,NL Vujanovic,

For similar peptides: intercellular signaling peptides and proteins: cytokines: tumor necrosis factors research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: tumor necrosis factors research

PUBMED ID PMID:

MEDLINE DATE:

Essential role of the TNF-TNFR2 cognate interaction in mouse dendritic cell-natural killer cell crosstalk. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Blood

VOLUME: 109

Page Numbers: 3333-41

Journal Abbreviation:

ISSN: 0006-4971

DAY: 12

MONTH: 12

YEAR: 2006

Essential role of the TNF-TNFR2 cognate interaction in mouse dendritic cell-natural killer cell crosstalk. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7603509

Essential role of the TNF-TNFR2 cognate interaction in mouse dendritic cell-natural killer cell crosstalk. Keywords Mesh Terms:

KEYWORDS: Tumor Necrosis Factors

MESH TERMS: immunology

Chemical & Substance for Abstract: Essential role of the TNF-TNFR2 cognate interaction in mouse dendritic cell-natural killer cell crosstalk. Information

Substance Name: Interferon Type II

Registry Number: 82115-62-6

Grant and Affiliation Information for Essential role of the TNF-TNFR2 cognate interaction in mouse dendritic cell-natural killer cell crosstalk.

AFFILIATION: University of Pittsburgh Cancer Institute, Hillman Cancer Center, 5117 Centre Avenue, Pittsburgh, PA, USA.

Country: United States

AGENCY: United States NIDCR

GRANT: R01 DE 14775

ACRONYM: DE

MEDLINETA: Blood

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Essential role of the TNF-TNFR2 cognate interaction in mouse dendritic cell-natural killer cell crosstalk Related Publications

• Constitutive expression and role of the TNF family ligands in apoptotic killing of tumor cells by human NK cells.
• Essential role of the TNF-TNFR2 cognate interaction in mouse dendritic cell-natural killer cell crosstalk.
• Linkages between cigarette smoking outcome expectancies and negative emotional vulnerability.