Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling.

Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling. Research Abstract Details 

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Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling. Abstract Text:

Tatsukata Kawagoe,Shintaro Sato,Andreas Jung,Masahiro Yamamoto,Kosuke Matsui,Hiroki Kato,Satoshi Uematsu,Osamu Takeuchi,Shizuo Akira,Tatsukata Kawagoe,Shintaro Sato,Andreas Jung,Masahiro Yamamoto,Kosuke Matsui,Hiroki Kato,Satoshi Uematsu,Osamu Takeuchi,Shizuo Akira,

Interleukin-1 receptor-associated kinase 4 (IRAK-4) was reported to be essential for the Toll-like receptor (TLR)- and T cell receptor (TCR)-mediated signaling leading to the activation of nuclear factor kappaB (NF-kappaB). However, the importance of kinase activity of IRAK family members is unclear. In this study, we investigated the functional role of IRAK-4 activity in vivo by generating mice carrying a knockin mutation (KK213AA) that abrogates its kinase activity. IRAK-4(KN/KN) mice were highly resistant to TLR-induced shock response. The cytokine production in response to TLR ligands was severely impaired in IRAK-4(KN/KN) as well as IRAK-4(-/-) macrophages. The IRAK-4 activity was essential for the activation of signaling pathways leading to mitogen-activated protein kinases. TLR-induced IRAK-4/IRAK-1-dependent and -independent pathways were involved in early induction of NF-kappaB-regulated genes in response to TLR ligands such as tumor necrosis factor alpha and IkappaBzeta. In contrast to a previous paper (Suzuki, N., S. Suzuki, D.G. Millar, M. Unno, H. Hara, T. Calzascia, S. Yamasaki, T. Yokosuka, N.J. Chen, A.R. Elford, et al. 2006. Science. 311:1927-1932), the TCR signaling was not impaired in IRAK-4(-/-) and IRAK-4(KN/KN) mice. Thus, the kinase activity of IRAK-4 is essential for the regulation of TLR-mediated innate immune responses.

Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling. Publishing Authors By Initials

T Kawagoe,S Sato,A Jung,M Yamamoto,K Matsui,H Kato,S Uematsu,O Takeuchi,S Akira,T Kawagoe,S Sato,A Jung,M Yamamoto,K Matsui,H Kato,S Uematsu,O Takeuchi,S Akira,

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Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of experimental medicine

VOLUME: 204

Page Numbers: 1013-24

Journal Abbreviation: J. Exp. Med.

ISSN: 0022-1007

DAY: 7

MONTH: 05

YEAR: 2007

Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling. Information

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LANGUAGE: eng

NlmUniqueID: 2985109

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Grant and Affiliation Information for Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling.

AFFILIATION: Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan.

Country: United States

AGENCY: United States NIAID

GRANT: AI070167

ACRONYM: AI

MEDLINETA: J Exp Med

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