Essential role for platelets in organ injury and inflammation in resuscitated hemorrhagic shock.

Essential role for platelets in organ injury and inflammation in resuscitated hemorrhagic shock. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Essential role for platelets in organ injury and inflammation in resuscitated hemorrhagic shock. Abstract Text:

David J Tweardy,Mohammad R Khoshnevis,Bi Yu,Mary-Ann A Mastrangelo,Edith G Hardison, ,

Platelets are known to contribute to ischemia/reperfusion in several organs, but their role in inflammation and organ injury after hemorrhagic shock (HS) has not been examined. To address this issue, we rendered mice thrombocytopenic (20% of normal platelet count) by treatment with pOp3, a rat monoclonal antibody against platelet glycoprotein Ibalpha, 24 h before subjecting them to either a standard HS or sham protocol. Liver apoptosis increased 3- to 5-fold (P<0.05), and focal liver necrosis increased 11-fold (P<0.01) in placebo-treated shock mice compared with sham; these increased indices of liver injury were completely prevented by pOp3 pretreatment. Neutrophils infiltrating the liver increased nearly 3-fold in placebo-treated shock mice versus sham (P<0.05); this shock-induced increase in neutrophil infiltration was also eliminated by pretreatment with pOp3. Alveolar cross-sectional area, used to histologically assess interstitial lung edema and cellular infiltration, was reduced by 25% in pOp3-treated shock mice versus placebo-treated shock mice (P<0.05). Similar to the results in liver, pOp3 pretreatment decreased neutrophil infiltration in the lung after HS. Thus, platelets contribute to the inflammatory injuries of the liver and lung after HS, in part, perhaps by facilitating neutrophil infiltration into tissues.

Essential role for platelets in organ injury and inflammation in resuscitated hemorrhagic shock. Publishing Authors By Initials

DJ Tweardy,MR Khoshnevis,B Yu,MA Mastrangelo,EG Hardison,JA ,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Essential role for platelets in organ injury and inflammation in resuscitated hemorrhagic shock. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Shock (Augusta, Ga.)

VOLUME: 26

Page Numbers: 386-90

Journal Abbreviation:

ISSN: 1073-2322

DAY: 3

MONTH: Oct

YEAR: 2006

Essential role for platelets in organ injury and inflammation in resuscitated hemorrhagic shock. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9421564

Essential role for platelets in organ injury and inflammation in resuscitated hemorrhagic shock. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Essential role for platelets in organ injury and inflammation in resuscitated hemorrhagic shock. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Essential role for platelets in organ injury and inflammation in resuscitated hemorrhagic shock.

AFFILIATION: Section of Infectious Diseases, Baylor College of Medicine, Houston, TX 77030, USA. dtweardy@bcm.edu

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Shock

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Essential role for platelets in organ injury and inflammation in resuscitated hemorrhagic shock Related Publications

• A unique mucin immunoenhancing peptide with antitumor properties.
• Comparative effects of nacre water-soluble matrix and dexamethasone on the alkaline phosphatase activity of MRC-5 fibroblasts.
• Copper, zinc, calcium and magnesium content of alcoholic beverages and by-products from Spain: nutritional supply.
• Cysticercosis in a female Nicaraguan traveler.
• Depression and anxiety in women with breast cancer and their partners.
• Determination of impurities in phenacetin by high-performance liquid chromatography.
• Differential mortality in Iran.
• Effect of branching and confinement on star-branched polymeric systems.
• Effect of kainic acid treatment on insulin-like growth factor-2 receptors in the IGF2-deficient adult mouse brain.
• Elevated resting [Ca(2+)](i) in myotubes expressing malignant hyperthermia RyR1 cDNAs is partially restored by modulation of passive calcium leak from the SR.
• Essential role for platelets in organ injury and inflammation in resuscitated hemorrhagic shock.
• Evaluation of the quality of cause of death statistics in rural China using verbal autopsies.
• Family interventions for serious mental illness: translating research to practice.
• Igf2 deficiency results in delayed lung development at the end of gestation.
• Jugular vein catheterization for hemodialysis: correct positioning control using real-time ultrasound guidance.
• Microvesicle-associated tissue factor and Trousseau's syndrome.
• Neighborhood risk factors for obesity.
• Pharmacologic and functional characterization of malignant hyperthermia in the R163C RyR1 knock-in mouse.
• Postdrinking sexual perceptions and behaviors toward another person: alcohol expectancy set and gender differences.
• Revision of chemotherapy in early stages neoadjuvant therapy.
• Scent may signal fighting ability in male Iberian rock lizards.
• Self-association processes involving anthracene labeled phosphatidylcholines in model membrane.
• Social networks, support, and psychosocial functioning among American Indian women in treatment.
• Substance abuse prevention intervention research with Hispanic populations.
• Tip position of long-term central venous access devices used for parenteral nutrition.
• Using bicellar mixtures to form supported and suspended lipid bilayers on silicon chips.
• Validation of cause-of-death statistics in urban China.
• [Darbepoetin alfa at weekly fixed doses. Clinical experience in Spanish centers.]
• [Postoperative serum vascular endothelial growth factor can be a marker for colorectal cancer recurrence]
• [Self-regulation systems to control tobacco advertising. An empirical analysis.]