Essential fatty acids and epidermal integrity.

Essential fatty acids and epidermal integrity. Research Abstract Details 

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Essential fatty acids and epidermal integrity. Abstract Text:

The intercellular spaces of the stratum corneum contain multilamellar lipid sheets derived from the extruded contents of lamellar granules. In the absence of linoleic acid, lamellar granules appear empty, and only fragmentary extracellular sheets are found. This defective differentiation is attributable to substitution of oleate for linoleate in O-acylsphingolipids. Normally, linoleate is ester-linked to 30- to 34-carbon omega-hydroxyacids, which, in turn, are amide-linked to sphingosine. Acylglucosylceramides, bearing a beta-D-glucosyl moiety on the sphingosine, may provide the driving force for lamellar granule assembly. The omega-hydroxyacyl chains are long enough to span a lipid bilayer, while the linoleate inserts into an adjacent bilayer. This interaction could promote assembly of lamellar granules. It has also been proposed that acylceramides may stabilize the extracellular sheets by a similar mechanism. In addition, the horny cell has been found to possess a covalently bound lipid envelope consisting principally of omega-hydroxyacylsphingosines derived from O-acylsphingolipids.

Essential fatty acids and epidermal integrity. Publishing Authors By Initials

For similar lipids: membrane lipids: sphingolipids research abstracts see: lipids: membrane lipids: sphingolipids research

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Essential fatty acids and epidermal integrity. Journal Published:

PUBLICATION TYPE: Review

Journal: Archives of dermatology

VOLUME: 123

Page Numbers: 1381-4

Journal Abbreviation: Arch Dermatol

ISSN: 0003-987X

DAY: 17

MONTH: Oct

YEAR: 1987

Essential fatty acids and epidermal integrity. Information

Number of References: 42

LANGUAGE: eng

NlmUniqueID: 372433

Essential fatty acids and epidermal integrity. Keywords Mesh Terms:

KEYWORDS: Sphingolipids

MESH TERMS: metabolism

Chemical & Substance for Abstract: Essential fatty acids and epidermal integrity. Information

Substance Name: Linoleic Acid

Registry Number: 2197-37-7

Grant and Affiliation Information for Essential fatty acids and epidermal integrity.

AFFILIATION: Department of Dermatology, Marshall Dermatology Research Laboratories, University of Iowa College of Medicine, Iowa City 52242.

Country: UNITED STATES

AGENCY: United States NIADDK

GRANT: AM 32374

ACRONYM: AM

MEDLINETA: Arch Dermatol

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