Essential and expendable features of the circadian timekeeping mechanism.

Essential and expendable features of the circadian timekeeping mechanism. Research Abstract Details 

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Essential and expendable features of the circadian timekeeping mechanism. Abstract Text:

Paul E Hardin,

Circadian clocks control behavioral, physiological and metabolic rhythms via one or more transcriptional feedback loops. In animals, two conserved feedback loops are thought to keep circadian time by mediating rhythmic transcription in opposite phases of the circadian cycle. Recent work in cyanobacteria nevertheless demonstrates that rhythmic transcription is dispensable for circadian timekeeping, raising the possibility that some features of the transcriptional feedback loops in animals are also expendable. Indeed, one of the two feedback loops is not necessary for circadian timekeeping in animals, but rhythmic transcription and post-translational modifications are both essential for keeping circadian time. These results not only confirm additional requirements within the animal circadian timekeeping mechanism, but also raise important questions about the function of conserved, yet expendable, features of the circadian timekeeping mechanism in animals.

Essential and expendable features of the circadian timekeeping mechanism. Publishing Authors By Initials

PE Hardin,

For similar proteins: transcription factors research abstracts see: proteins: transcription factors research

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Essential and expendable features of the circadian timekeeping mechanism. Journal Published:

PUBLICATION TYPE: Review

Journal: Current opinion in neurobiology

VOLUME: 16

Page Numbers: 686-92

Journal Abbreviation: Curr. Opin. Neurobiol.

ISSN: 0959-4388

DAY: 29

MONTH: 09

YEAR: 2006

Essential and expendable features of the circadian timekeeping mechanism. Information

Number of References: 48

LANGUAGE: eng

NlmUniqueID: 9111376

Essential and expendable features of the circadian timekeeping mechanism. Keywords Mesh Terms:

KEYWORDS: Transcription Factors

MESH TERMS: metabolism

Chemical & Substance for Abstract: Essential and expendable features of the circadian timekeeping mechanism. Information

Substance Name: period protein, insect

Registry Number: 0

Grant and Affiliation Information for Essential and expendable features of the circadian timekeeping mechanism.

AFFILIATION: Department of Biology, Center for Research on Biological Clocks, Texas A&M University, College Station, TX 77843-3258, USA. phardin@mail.bio.tamu.edu

Country: England

AGENCY: United States NINDS

GRANT: NS052854

ACRONYM: NS

MEDLINETA: Curr Opin Neurobiol

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