Erythropoietin receptor expression in the human urogenital tract: immunolocalization in the prostate, neurovascular bundle and penis.

Erythropoietin receptor expression in the human urogenital tract: immunolocalization in the prostate, neurovascular bundle and penis. Research Abstract Details 

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Erythropoietin receptor expression in the human urogenital tract: immunolocalization in the prostate, neurovascular bundle and penis. Abstract Text:

Tongyun Liu,Mohamad E Allaf,Gwen Lagoda,Arthur L Burnett,Tongyun Liu,Mohamad E Allaf,Gwen Lagoda,Arthur L Burnett,

OBJECTIVE: To investigate whether the erythropoietin (EPO) receptor is expressed in human periprostatic (including the neurovascular bundles) and penile tissues, and define its distribution in these tissues, as the administration of exogenous EPO in cavernous nerve injury promoted the recovery of erectile function in a rat model. MATERIALS AND METHODS: Human prostate (six samples) and penile (two) tissue were collected and paraffin-embedded. Tissue was sectioned and processed for immunohistochemical studies using an antibody for the EPO receptor; immunolocalization was assessed using light microscopy. RESULTS: There was prominent staining for the EPO receptor in neuronal cell bodies of the periprostatic neurovascular bundles, and in the axons emanating from these ganglia. The glandular epithelium of the prostate also had weak staining. There was EPO receptor immunoreactivity in the penile specimens in the penile dorsal nerves, sinusoidal endothelium of the corpus cavernosum, and endothelial cells lining the dorsal veins and arteries. All slides processed with no primary antibody or blocking peptide showed no staining. CONCLUSIONS: EPO receptor expression was identified and localized in human penile tissues and in the periprostatic neurovascular bundles responsible for erectile function. This suggests a likely role for endogenous EPO within these tissues, and provides the rationale for its clinical use as a protective agent locally.

Erythropoietin receptor expression in the human urogenital tract: immunolocalization in the prostate, neurovascular bundle and penis. Publishing Authors By Initials

T Liu,ME Allaf,G Lagoda,AL Burnett,T Liu,ME Allaf,G Lagoda,AL Burnett,

For similar proteins: membrane proteins: receptors, cell surface: receptors, immunologic: receptors, cytokine: receptors, colony-stimulating factor: receptors, erythropoietin research abstracts see: proteins: membrane proteins: receptors, cell surface: receptors, immunologic: receptors, cytokine: receptors, colony-stimulating factor: receptors, erythropoietin research

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Erythropoietin receptor expression in the human urogenital tract: immunolocalization in the prostate, neurovascular bundle and penis. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: BJU international

VOLUME: 100

Page Numbers: 1103-6

Journal Abbreviation: BJU Int.

ISSN: 1464-4096

DAY: 14

MONTH: 09

YEAR: 2007

Erythropoietin receptor expression in the human urogenital tract: immunolocalization in the prostate, neurovascular bundle and penis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100886721

Erythropoietin receptor expression in the human urogenital tract: immunolocalization in the prostate, neurovascular bundle and penis. Keywords Mesh Terms:

KEYWORDS: Receptors, Erythropoietin

MESH TERMS: analysis

Chemical & Substance for Abstract: Erythropoietin receptor expression in the human urogenital tract: immunolocalization in the prostate, neurovascular bundle and penis. Information

Substance Name: Receptors, Erythropoietin

Registry Number: 0

Grant and Affiliation Information for Erythropoietin receptor expression in the human urogenital tract: immunolocalization in the prostate, neurovascular bundle and penis.

AFFILIATION: James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.

Country: England

AGENCY: United States PHS

GRANT: 064679

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MEDLINETA: BJU Int

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