Erythropoietin modulation of podocalyxin and a proposed erythroblast niche.

Erythropoietin modulation of podocalyxin and a proposed erythroblast niche. Research Abstract Details 

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Erythropoietin modulation of podocalyxin and a proposed erythroblast niche. Abstract Text:

Pradeep Sathyanarayana,Madhu P Menon,Olga Bogacheva,Oleg Bogachev,Knut Niss,William S Kapelle,Estelle Houde,Jing Fang,Don M Wojchowski,

Epo's erythropoietic capacity is ascribed largely to its antiapoptotic actions. In part via gene profiling of bone marrow erythroblasts, Epo is now shown to selectively down-modulate the adhesion/migration factors chemokine receptor-4 (Cxcr4) and integrin alpha-4 (Itga4) and to up-modulate growth differentiation factor-3 (Gdf3), oncostatin-M (OncoM), and podocalyxin like-1 (PODXL). For PODXL, Epo dose-dependent expression of this CD34-related sialomucin was discovered in Kit(+)CD71(high) proerythroblasts and was sustained at subsequent Kit(-)CD71(high) and Ter119(+) stages. In vivo, Epo markedly induced PODXL expression in these progenitors and in marrow-resident reticulocytes. This was further associated with a rapid release of PODXL(+) reticulocytes to blood. As studied in erythroblasts expressing minimal Epo receptor (EpoR) alleles, efficient PODXL induction proved dependence on an EpoR-PY343 Stat5 binding site. Moreover, in mice expressing an EpoR-HM F343 allele, compromised Epo-induced PODXL expression correlated with abnormal anucleated red cell representation in marrow. By modulating this select set of cell-surface adhesion molecules and chemokines, Epo is proposed to mobilize erythroblasts from a hypothesized stromal niche and possibly promote reticulocyte egress to blood.

Erythropoietin modulation of podocalyxin and a proposed erythroblast niche. Publishing Authors By Initials

P Sathyanarayana,MP Menon,O Bogacheva,O Bogachev,K Niss,WS Kapelle,E Houde,J Fang,DM Wojchowski,

For similar mucoproteins: mucins: sialomucins research abstracts see: mucoproteins: mucins: sialomucins research

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Erythropoietin modulation of podocalyxin and a proposed erythroblast niche. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Blood

VOLUME: 110

Page Numbers: 509-18

Journal Abbreviation: Blood

ISSN: 0006-4971

DAY: 2

MONTH: 04

YEAR: 2007

Erythropoietin modulation of podocalyxin and a proposed erythroblast niche. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7603509

Erythropoietin modulation of podocalyxin and a proposed erythroblast niche. Keywords Mesh Terms:

KEYWORDS: Sialomucins

MESH TERMS: genetics

Chemical & Substance for Abstract: Erythropoietin modulation of podocalyxin and a proposed erythroblast niche. Information

Substance Name: Erythropoietin

Registry Number: 11096-26-7

Grant and Affiliation Information for Erythropoietin modulation of podocalyxin and a proposed erythroblast niche.

AFFILIATION: Stem and Progenitor Cell Biology Program and Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, ME 04074, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: R01 HL044491

ACRONYM: HL

MEDLINETA: Blood

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• Erythropoietin modulation of podocalyxin and a proposed erythroblast niche.