Erythropoietin attenuates the development of experimental autoimmune myocarditis.

Erythropoietin attenuates the development of experimental autoimmune myocarditis. Research Abstract Details 

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Erythropoietin attenuates the development of experimental autoimmune myocarditis. Abstract Text:

Sho-Ichi Hirose,Masafumi Takahashi,Ryo Ogawa,Hajime Morimoto,Atsushi Izawa,Hajime Sato,Hirohiko Ise,Minoru Hongo,Uichi Ikeda,

OBJECTIVE: Erythropoietin (EPO) has been shown to not only have cardioprotective effects but also attenuate autoimmune diseases. In the present study, we investigated the effect of EPO on cardiac inflammation and function, inflammatory cell infiltration, and cytokine expression in a rat model of experimental autoimmune myocarditis (EAM). METHODS AND RESULTS: Male Lewis rats (6-8 weeks old) were immunized on day 0 with porcine cardiac myosin to establish EAM. The rats were subcutaneously administered either vehicle (saline) or human recombinant EPO (6,000 U/kg, 3 days/week) from day 0 to 20, and they were evaluated on day 21. In the EPO group, the inflammation area and heart weight/body weight ratio were significantly attenuated as compared with those in the vehicle group. Blood pressure and cardiac function were also improved in the EPO group. Immunohistochemistry revealed that EPO decreased the infiltration of macrophages and CD4 T cells, and degranulated mast cells in the myocardium. Real-time RT-PCR analysis demonstrated that inflammatory cytokine expression in the myocardium and lymphocytes was suppressed in the EPO group. However, in vitro experiments showed that EPO had no effect on antigen-induced proliferation and cytokine expression in lymphocytes. CONCLUSION: EPO attenuates inflammatory cell infiltration and cytokine expression, and it improves cardiac function and reduces cardiac inflammation in EAM. This beneficial effect of EPO is unlikely to arise from a direct anti-inflammatory action on lymphocytes. These findings suggest the therapeutic potential of EPO for the treatment of myocarditis.

Erythropoietin attenuates the development of experimental autoimmune myocarditis. Publishing Authors By Initials

S Hirose,M Takahashi,R Ogawa,H Morimoto,A Izawa,H Sato,H Ise,M Hongo,U Ikeda,

For similar circulatory and respiratory physiology: cardiovascular physiology: cardiovascular physiologic processes: ventricular function: ventricular function, left research abstracts see: circulatory and respiratory physiology: cardiovascular physiology: cardiovascular physiologic processes: ventricular function: ventricular function, left research

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Erythropoietin attenuates the development of experimental autoimmune myocarditis. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cardiovascular drugs and therapy / sponsored by th

VOLUME: 21

Page Numbers: 17-27

Journal Abbreviation:

ISSN: 0920-3206

DAY: 13

MONTH: 02

YEAR: 2007

Erythropoietin attenuates the development of experimental autoimmune myocarditis. Information

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LANGUAGE: eng

NlmUniqueID: 8712220

Erythropoietin attenuates the development of experimental autoimmune myocarditis. Keywords Mesh Terms:

KEYWORDS: Ventricular Function, Left

MESH TERMS: drug effects

Chemical & Substance for Abstract: Erythropoietin attenuates the development of experimental autoimmune myocarditis. Information

Substance Name: Cardiac Myosins

Registry Number: EC 3.6.1.-

Grant and Affiliation Information for Erythropoietin attenuates the development of experimental autoimmune myocarditis.

AFFILIATION: Division of Cardiovascular Sciences, Department of Organ Regeneration, Shinshu University Graduate School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan.

Country: United States

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MEDLINETA: Cardiovasc Drugs Ther

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