Erythropoietic activity of preparations containing receptors and antibodies to erythropoietin in ultralow doses.

Erythropoietic activity of preparations containing receptors and antibodies to erythropoietin in ultralow doses. Research Abstract Details 

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Erythropoietic activity of preparations containing receptors and antibodies to erythropoietin in ultralow doses. Abstract Text:

V V Zhdanov,E V Simanina,Yu L Dugina,L A Stavrova,L A Gur'yantseva,O I Epstein,A M Dygai,E D Goldberg,O L Voronova,O P Rogozina,Yu M Dugina,A V Martyushev,O I Epstein,A M Dygai,E D Goldberg,

We compared the erythropoiesis-stimulating effects of ultralow doses of erythropoietin receptors and antibodies to erythropoietin in intact mice. Antibodies to erythropoietin, but not erythropoietin receptors, possessed considerable erythropoiesis-activating properties. 75 76 EN, RU Mutagenic Activity of Potentiated Antibodies to Erythropoietin O. L. Voronova Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences; "Materia Medica Holding" Research-and-Production Company, Moscow O. P. Rogozina Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences; "Materia Medica Holding" Research-and-Production Company, Moscow Yu. M. Dugina Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences; "Materia Medica Holding" Research-and-Production Company, Moscow A. V. Martyushev Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences; "Materia Medica Holding" Research-and-Production Company, Moscow O. I. Epstein Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences; "Materia Medica Holding" Research-and-Production Company, Moscow A.M. Dygai Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences; "Materia Medica Holding" Research-and-Production Company, Moscow E.D. Goldberg Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences; "Materia Medica Holding" Research-and-Production Company, Moscow 2002 Single and repeated administration of ultralow doses of antibodies to erythropoietin did not increase the count of aberrant metaphases in bone marrow cells of BALB/c mice and were not genotoxic for Drosophila melanogaster wing cells in the test of somatic mosaicism.

Erythropoietic activity of preparations containing receptors and antibodies to erythropoietin in ultralow doses. Publishing Authors By Initials

VV Zhdanov,EV Simanina,YL Dugina,LA Stavrova,LA Gur'yantseva,OI Epstein,AM Dygai,ED Goldberg,OL Voronova,OP Rogozina,YM Dugina,AV Martyushev,OI Epstein,AM Dygai,ED Goldberg,

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Erythropoietic activity of preparations containing receptors and antibodies to erythropoietin in ultralow doses. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Bulletin of experimental biology and medicine

VOLUME: 135 Suppl 1

Page Numbers: 73-4

Journal Abbreviation: Bull. Exp. Biol. Med.

ISSN: 0007-4888

DAY: 1

MONTH: 09

YEAR: 2003

Erythropoietic activity of preparations containing receptors and antibodies to erythropoietin in ultralow doses. Information

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LANGUAGE: eng

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AFFILIATION: Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences; "Materia Medica Holding" Research-and-Production Company, Moscow.

Country: United States

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