Erythrocyte aging changes evaluated by the deoxyuridine suppression test.

Erythrocyte aging changes evaluated by the deoxyuridine suppression test. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Erythrocyte aging changes evaluated by the deoxyuridine suppression test. Abstract Text:

Many hematologic studies have shown that the erythrocyte count decreases while the size of the individual cell increases in the aged. This study was performed in order to (1) evaluate changes in the blood erythrocyte level and mean erythrocyte size in the elderly and (2) evaluate use of the deoxyuridine (dU) supression test to determine whether deficiency of vitamin B12 or folate plays any role in age-related changes of hematopoiesis. Selected for study were 102 healthy men whose ages ranged from 20 to 79 years. The erythrocyte count and hemoglobin level decreased significantly, whereas the mean corpuscular volume and mean corpuscular hemoglobin increased after 70 years of age. Fresh bone-marrow cells were obtained from 10 young (20-38 yr) and 10 aged (70-82 yr) men. Wickramasinghe's dU suppression test was modified by application of an automatic cell harvester. The results were normal in both groups. Thus, the route of dU to dTMP in a DNA synthetic pathway appeared intact, and there was no evidence of B12 or folate deficiency in the aged to explain the observed macrocytosis. However, 3H-thymidine uptake by nucleated bone-marrow cells was significantly decreased, and the ratio of 3H-uridine to 3H-thymidine uptake was greater in the old group than in the young group. These results could be explained by altered nucleic acid metabolism (unbalanced cell growth) or by a change in the proportion of the different fractions of nucleated cells.

Erythrocyte aging changes evaluated by the deoxyuridine suppression test. Publishing Authors By Initials

For similar nutritional and metabolic diseases: nutrition disorders: malnutrition: deficiency diseases: avitaminosis: vitamin b deficiency: vitamin b 12 deficiency research abstracts see: nutritional and metabolic diseases: nutrition disorders: malnutrition: deficiency diseases: avitaminosis: vitamin b deficiency: vitamin b 12 deficiency research

PUBMED ID PMID:

MEDLINE DATE:

Erythrocyte aging changes evaluated by the deoxyuridine suppression test. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of the American Geriatrics Society

VOLUME: 30

Page Numbers: 626-31

Journal Abbreviation: J Am Geriatr Soc

ISSN: 0002-8614

DAY: 10

MONTH: Oct

YEAR: 1982

Erythrocyte aging changes evaluated by the deoxyuridine suppression test. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7503062

Erythrocyte aging changes evaluated by the deoxyuridine suppression test. Keywords Mesh Terms:

KEYWORDS: Vitamin B 12 Deficiency

MESH TERMS: diagnosis

Chemical & Substance for Abstract: Erythrocyte aging changes evaluated by the deoxyuridine suppression test. Information

Substance Name: Deoxyuridine

Registry Number: 951-78-0

Grant and Affiliation Information for Erythrocyte aging changes evaluated by the deoxyuridine suppression test.

AFFILIATION:

Country: UNITED STATES

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Am Geriatr Soc

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Erythrocyte aging changes evaluated by the deoxyuridine suppression test Related Publications

• D-Glutamic acid-induced muscle contraction in the silkworm, Bombyx mori.
• Differential Involvement of Cell Cycle Reactivation between Striatal and Cortical Neurons in Cell Death Induced by 3-Nitropropionic Acid.
• Erythrocyte aging changes evaluated by the deoxyuridine suppression test.
• Ethanol enhances reactivated fear memories.
• Metabolism of triacylglycerol in Mycobacterium smegmatis.
• Novel transcript profiling of diffuse alveolar damage induced by hyperoxia exposure in mice: normalization by glyceraldehyde 3-phosphate dehydrogenase.
• Phospholipid deacylating activities in murine leprosy bacilli.
• Protein kinase CK2 modulates synaptic plasticity by modification of synaptic NMDA receptors in the hippocampus.
• Renin and the juxtaglomerular apparatus in diabetic nephropathy.
• Repeatability of measurements of the initial distribution volume of glucose in haemodynamically stable patients.
• Role of adrenergic mechanism in ketogenesis.
• [Application and evaluation of Roy's nursing theory--an observation at a U. S. institution where the theory is practiced]
• [Application and evaluation of Roy's theory of nursing--observation of the facilities where the theory is applied in the United States]
• [Colorectal cancer--CT, MRI diagnosis and surgery]
• [Current topics in clinical training in nursing. Grading in clinical training]
• [EXPERIMENTAL USE OF 8909 RP, A NEW PHENOTHIAZINE COMPOUND, FOR THE TREATMENT OF MENTAL DISORDERS.]
• [Jennerian vaccination introduced via the trans-Siberian route by Goroji Nakagawa--his influence on the first successful vaccination by Teisai Hino in Kyoto]
• [Keypoint in the teaching plan: planning of more effective teaching program]
• [Nurse practitioner as a practice model of health for all]
• [Significance of Roy's nursing theory in Japanese nursing education]
• [Sleep and anesthesia--part 2, on the relationship between sleep and general anesthesia]
• [The problem of continuity in primary nursing]