Eruptive papules during efalizumab (anti-CD11a) therapy of psoriasis vulgaris: a case series.

Eruptive papules during efalizumab (anti-CD11a) therapy of psoriasis vulgaris: a case series. Research Abstract Details 

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Eruptive papules during efalizumab (anti-CD11a) therapy of psoriasis vulgaris: a case series. Abstract Text:

Michelle A Lowes,Francesca Chamian,Maria V Abello,Craig Leonardi,Wolfgang Dummer,Kim Papp,James G Krueger,

BACKGROUND: Newer biological therapies for moderate-to-severe psoriasis are being used more frequently, but unexpected effects may occur. CASE PRESENTATIONS: We present a group of 15 patients who developed inflammatory papules while on efalizumab therapy (Raptiva, Genentech Inc, anti-CD11a). Immunohistochemistry showed that there were increased CD11b+, CD11c+ and iNOS+ cells (myeloid leukocytes) in the papules, with relatively few CD3+ T cells. While efalizumab caused a decreased expression of CD11a on T cells, other circulating leukocytes from patients receiving this therapy often showed increased CD11b and CD11c. In the setting of an additional stimulus such as skin trauma, this may predispose to increased trafficking into the skin using these alternative beta2 integrins. In addition, there may be impaired immune synapse formation, limiting the development of these lesions to small papules. There is little evidence for these papular lesions being "allergic" in nature as there are few eosinophils on biopsy, and they respond to minimal or no therapy even if efalizumab is continued. CONCLUSION: We hypothesize that these papules may represent a unique type of "mechanistic" inflammatory reaction, seen only in the context of drug-induced CD11a blockade, and not during the natural disease process.

Eruptive papules during efalizumab (anti-CD11a) therapy of psoriasis vulgaris: a case series. Publishing Authors By Initials

MA Lowes,F Chamian,MV Abello,C Leonardi,W Dummer,K Papp,JG Krueger,

For similar cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes research abstracts see: cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes research

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Eruptive papules during efalizumab (anti-CD11a) therapy of psoriasis vulgaris: a case series. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: BMC dermatology

VOLUME: 7

Page Numbers: 2

Journal Abbreviation: BMC Dermatol.

ISSN: 1471-5945

DAY: 26

MONTH: 02

YEAR: 2007

Eruptive papules during efalizumab (anti-CD11a) therapy of psoriasis vulgaris: a case series. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100968541

Eruptive papules during efalizumab (anti-CD11a) therapy of psoriasis vulgaris: a case series. Keywords Mesh Terms:

KEYWORDS: T-Lymphocytes

MESH TERMS: pathology

Chemical & Substance for Abstract: Eruptive papules during efalizumab (anti-CD11a) therapy of psoriasis vulgaris: a case series. Information

Substance Name: Nitric Oxide Synthase Type II

Registry Number: EC 1.14.13.39

Grant and Affiliation Information for Eruptive papules during efalizumab (anti-CD11a) therapy of psoriasis vulgaris: a case series.

AFFILIATION: Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York, USA. jgk@rockefeller.edu.

Country: England

AGENCY: United States NIAID

GRANT: R01 AI-49572

ACRONYM: AI

MEDLINETA: BMC Dermatol

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