Erbin controls dendritic morphogenesis by regulating localization of delta-catenin.

Erbin controls dendritic morphogenesis by regulating localization of delta-catenin. Research Abstract Details 

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Erbin controls dendritic morphogenesis by regulating localization of delta-catenin. Abstract Text:

The LAP [leucine-rich and postsynaptic density-95/Discs large/zona occludens-1 (PDZ)] protein erbin and delta-catenin, a component of the cadherin-catenin cell adhesion complex, are highly expressed in neurons and associate through PDZ-mediated interaction, but have incompletely characterized neuronal functions. We show that short hairpin RNA-mediated knockdown of erbin and knockdown or genetic ablation of delta-catenin severely impaired dendritic morphogenesis in hippocampal neurons. Simultaneous loss of erbin and delta-catenin does not enhance severity of this phenotype. The dendritic phenotype observed after erbin depletion is rescued by overexpression of delta-catenin and requires a domain in delta-catenin that has been shown to regulate dendritic branching. Knockdown of delta-catenin cannot be rescued by overexpression of erbin, indicating that erbin is upstream of delta-catenin. delta-Catenin-null neurons have no alterations in global levels of active Rac1/RhoA. Knockdown of erbin results in alterations in localization of delta-catenin. These results suggest a critical role for erbin in regulating dendritic morphogenesis by maintaining appropriate localization of delta-catenin.

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Erbin controls dendritic morphogenesis by regulating localization of delta-catenin. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of neuroscience : the official journal

VOLUME: 28

Page Numbers: 7047-56

Journal Abbreviation: J. Neurosci.

ISSN: 1529-2401

DAY: 9

MONTH: Jul

YEAR: 2008

Erbin controls dendritic morphogenesis by regulating localization of delta-catenin. Information

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LANGUAGE: eng

NlmUniqueID: 8102140

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Grant and Affiliation Information for Erbin controls dendritic morphogenesis by regulating localization of delta-catenin.

AFFILIATION: Department of Physiology, University of California, San Francisco, San Francisco, California 94158, USA. louis.reichardt@ucsf.edu

Country: United States

AGENCY: United States Howard Hugh

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MEDLINETA: J Neurosci

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