ErbB receptor regulation by dexamethasone in mouse type II epithelial cells.

ErbB receptor regulation by dexamethasone in mouse type II epithelial cells. Research Abstract Details 

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ErbB receptor regulation by dexamethasone in mouse type II epithelial cells. Abstract Text:

C E L Dammann,N Nassimi,W Liu,H C Nielsen,

Glucocorticoids stimulate foetal surfactant synthesis. Therefore, they are used in impending pre-term birth. One mechanism of action on surfactant synthesis is through the induction of neuregulin (NRG) secretion by foetal lung fibroblasts. The direct effects on signalling pathways, and specifically on erbB receptors in foetal type II cell surfactant synthesis, are less well understood. The present authors studied the effect of known promoters of foetal surfactant synthesis (namely dexamethasone and mature (i.e. NRG-containing) fibroblast-conditioned medium (FCM)) on erbB receptor activation, protein content and dimerisation patterns in foetal mouse lung type II cells. Dexamethasone inhibited surfactant synthesis in immature type II cells at day (d)16 of gestation, while the mature FCM had stimulatory effects. Both treatments directly stimulated surfactant synthesis in more mature (d17) cells. At this gestational day, dexamethasone had only a small effect on phosphorylation, but it stimulated the protein levels of all four erbB receptors. Dexamethasone effects were distinct from those of mature FCM, which stimulated both protein content and phosphorylation of all erbB receptors and of the signalling intermediate phospholipase Cgamma. Dexamethasone modulated erbB receptor dimerisation patterns, such that erbB2 became the main dimerisation partner for erbB4. In conclusion, dexamethasone signalling involves erbB receptors in foetal type II cells, in a manner similar to, but distinct from, neuregulin-containing fibroblast-conditioned medium signalling.

ErbB receptor regulation by dexamethasone in mouse type II epithelial cells. Publishing Authors By Initials

CE Dammann,N Nassimi,W Liu,HC Nielsen,

For similar biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research abstracts see: biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research

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MEDLINE DATE:

ErbB receptor regulation by dexamethasone in mouse type II epithelial cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The European respiratory journal : official journa

VOLUME: 28

Page Numbers: 1117-23

Journal Abbreviation: Eur. Respir. J.

ISSN: 0903-1936

DAY: 9

MONTH: 08

YEAR: 2006

ErbB receptor regulation by dexamethasone in mouse type II epithelial cells. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8803460

ErbB receptor regulation by dexamethasone in mouse type II epithelial cells. Keywords Mesh Terms:

KEYWORDS: Signal Transduction

MESH TERMS: metabolism

Chemical & Substance for Abstract: ErbB receptor regulation by dexamethasone in mouse type II epithelial cells. Information

Substance Name: Receptor, erbB-2

Registry Number: EC 2.7.1.112

Grant and Affiliation Information for ErbB receptor regulation by dexamethasone in mouse type II epithelial cells.

AFFILIATION: Division of Newborn Medicine, Tufts University and Floating Hospital for Children, Boston, MA, USA. dammann.christiane@mh-hannover.de

Country: Switzerland

AGENCY: United States NHLBI

GRANT: HL 37930

ACRONYM: HL

MEDLINETA: Eur Respir J

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