ErbB-2 induces the cyclin D1 gene in prostate epithelial cells in vitro and in vivo.

ErbB-2 induces the cyclin D1 gene in prostate epithelial cells in vitro and in vivo. Research Abstract Details 

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ErbB-2 induces the cyclin D1 gene in prostate epithelial cells in vitro and in vivo. Abstract Text:

Mathew Casimiro,Olga Rodriguez,Llana Pootrakul,Maral Aventian,Nadia Lushina,Caroline Cromelin,Georgina Ferzli,Kevin Johnson,Stanley Fricke,Fantahun Diba,Bhaskar Kallakury,Chioma Ohanyerenwa,Maxine Chen,Michael Ostrowski,Mien-Chie Hung,Shafaat A Rabbani,Ram Datar,Richard Cote,Richard Pestell,Chris Albanese,

The receptor tyrosine kinase ErbB-2 plays an important role in the regulation of growth factor-induced signal transduction cascades in the epithelium, and ErbB-2 is frequently overexpressed in epithelial tumors. Our previous studies on clinical prostate cancer specimens indicated that ErbB-2 expression was increased in patients undergoing hormone ablation therapy. We had also shown that the critical cell cycle regulatory gene cyclin D1 and its promoter were targets of proliferative signaling in prostate cancer cell lines, and that cyclin D1 was required for ErbB-2-induced mammary tumorigenesis. In the current studies, we found that increased ErbB-2 membrane expression correlated with increased nuclear cyclin D1 staining in clinical prostate cancer specimens, and that expression of ErbB-2 was capable of inducing cell cycle progression in human prostate cancer cell lines. We further showed that ErbB-2 induced the cyclin D1 promoter in DU145 cells, and that small interfering RNA knockdown of cyclin D1 protein levels blocked a significant proportion of the heregulin-induced cell cycle progression in LNCaP cells. Probasin promoter-targeted expression of an activated ErbB-2 isoform induced cyclin D1 expression in the mouse prostate, commensurate with prostate intraepithelial neoplasia. Together, these in vitro and in vivo studies identify cyclin D1 as a critical downstream target of ErbB-2 in the prostate epithelium, both of which are possible therapeutic targets for cancer intervention. Furthermore, our novel mouse model provides a useful platform for ongoing in vivo investigations of ErbB-2 signaling in the prostate epithelium.

ErbB-2 induces the cyclin D1 gene in prostate epithelial cells in vitro and in vivo. Publishing Authors By Initials

M Casimiro,O Rodriguez,L Pootrakul,M Aventian,N Lushina,C Cromelin,G Ferzli,K Johnson,S Fricke,F Diba,B Kallakury,C Ohanyerenwa,M Chen,M Ostrowski,MC Hung,SA Rabbani,R Datar,R Cote,R Pestell,C Albanese,

For similar enzymes and coenzymes: enzymes: transferases: phosphotransferases: phosphotransferases (alcohol group acceptor): protein kinases: protein-tyrosine kinases: receptor protein-tyrosine kinases: receptor, erbb-2 research abstracts see: enzymes and coenzymes: enzymes: transferases: phosphotransferases: phosphotransferases (alcohol group acceptor): protein kinases: protein-tyrosine kinases: receptor protein-tyrosine kinases: receptor, erbb-2 research

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MEDLINE DATE:

ErbB-2 induces the cyclin D1 gene in prostate epithelial cells in vitro and in vivo. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cancer research

VOLUME: 67

Page Numbers: 4364-72

Journal Abbreviation:

ISSN: 0008-5472

DAY: 1

MONTH: May

YEAR: 2007

ErbB-2 induces the cyclin D1 gene in prostate epithelial cells in vitro and in vivo. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2984705

ErbB-2 induces the cyclin D1 gene in prostate epithelial cells in vitro and in vivo. Keywords Mesh Terms:

KEYWORDS: Receptor, erbB-2

MESH TERMS: biosynthesis

Chemical & Substance for Abstract: ErbB-2 induces the cyclin D1 gene in prostate epithelial cells in vitro and in vivo. Information

Substance Name: Receptor, erbB-2

Registry Number: EC 2.7.1.112

Grant and Affiliation Information for ErbB-2 induces the cyclin D1 gene in prostate epithelial cells in vitro and in vivo.

AFFILIATION: Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Country: United States

AGENCY: United States NCI

GRANT: U54CA100970-02

ACRONYM: CA

MEDLINETA: Cancer Res

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