Epileptogenic effects of radiographic contrast agents: experimental study.

Epileptogenic effects of radiographic contrast agents: experimental study. Research Abstract Details 

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Epileptogenic effects of radiographic contrast agents: experimental study. Abstract Text:

R N Bryan,D Johnston,

Electrical activity in cells directly exposed to water-soluble radiographic contrast agents was investigated by intracellular recordings from neurons of the abdominal ganglia of Aplysia. Measurements of membrane resting potential, membrane conductance, synaptic and action potential configuration, and spontaneous electrical activity were performed. Test solutions included sodium diatrizoate, meglumine iothalamate, metrizamide, and control solutions. Solutions (100 and 200 mOsm) of these agents did not significantly alter resting membrane potential, membrane conductance, action potential frequency or configuration, or excitatory postsynaptic potentials. Inhibitory postsynaptic potentials were suppressed by contrast agents. These results suggest that contrast agents affect at least some neurons by disinhibition.

Epileptogenic effects of radiographic contrast agents: experimental study. Publishing Authors By Initials

RN Bryan,D Johnston,

For similar nervous system: neurons research abstracts see: nervous system: neurons research

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Epileptogenic effects of radiographic contrast agents: experimental study. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: AJNR. American journal of neuroradiology

VOLUME: 3

Page Numbers: 117-20

Journal Abbreviation:

ISSN: 0195-6108

DAY: 14

MONTH: 02

YEAR: 2008

Epileptogenic effects of radiographic contrast agents: experimental study. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8003708

Epileptogenic effects of radiographic contrast agents: experimental study. Keywords Mesh Terms:

KEYWORDS: Neurons

MESH TERMS: physiology

Chemical & Substance for Abstract: Epileptogenic effects of radiographic contrast agents: experimental study. Information

Substance Name: Contrast Media

Registry Number: 0

Grant and Affiliation Information for Epileptogenic effects of radiographic contrast agents: experimental study.

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Country: UNITED STATES

AGENCY: United States NINDS

GRANT: NS14907

ACRONYM: NS

MEDLINETA: AJNR Am J Neuroradiol

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