Epigenetic stem cell signature in cancer.

Epigenetic stem cell signature in cancer. Research Abstract Details 

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Epigenetic stem cell signature in cancer. Abstract Text:

Martin Widschwendter,Heidi Fiegl,Daniel Egle,Elisabeth Mueller-Holzner,Gilbert Spizzo,Christian Marth,Daniel J Weisenberger,Mihaela Campan,Joanne Young,Ian Jacobs,Peter W Laird,

Embryonic stem cells rely on Polycomb group proteins to reversibly repress genes required for differentiation. We report that stem cell Polycomb group targets are up to 12-fold more likely to have cancer-specific promoter DNA hypermethylation than non-targets, supporting a stem cell origin of cancer in which reversible gene repression is replaced by permanent silencing, locking the cell into a perpetual state of self-renewal and thereby predisposing to subsequent malignant transformation.

Epigenetic stem cell signature in cancer. Publishing Authors By Initials

M Widschwendter,H Fiegl,D Egle,E Mueller-Holzner,G Spizzo,C Marth,DJ Weisenberger,M Campan,J Young,I Jacobs,PW Laird,

For similar cells: stem cells research abstracts see: cells: stem cells research

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Epigenetic stem cell signature in cancer. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Nature genetics

VOLUME: 39

Page Numbers: 157-8

Journal Abbreviation: Nat. Genet.

ISSN: 1061-4036

DAY: 31

MONTH: 12

YEAR: 2006

Epigenetic stem cell signature in cancer. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9216904

Epigenetic stem cell signature in cancer. Keywords Mesh Terms:

KEYWORDS: Stem Cells

MESH TERMS: physiology

Chemical & Substance for Abstract: Epigenetic stem cell signature in cancer. Information

Substance Name: polycomb group proteins

Registry Number: 0

Grant and Affiliation Information for Epigenetic stem cell signature in cancer.

AFFILIATION: Department of Gynecological Oncology, Institute for Women's Health, University College London, London WC1E 6DH, UK. M.Widschwendter@ucl.ac.uk

Country: United States

AGENCY: United States NCI

GRANT: R01 CA075090

ACRONYM: CA

MEDLINETA: Nat Genet

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