Epigenetic regulation of tumor necrosis factor alpha.

Epigenetic regulation of tumor necrosis factor alpha. Research Abstract Details 

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Epigenetic regulation of tumor necrosis factor alpha. Abstract Text:

K E Sullivan,A B M Reddy,K Dietzmann,A R Suriano,V P Kocieda,M Stewart,M Bhatia,

Tumor necrosis factor alpha (TNF-alpha) is a potent cytokine which regulates inflammation via the induction of adhesion molecules and chemokine expression. Its expression is known to be regulated in a complex manner with transcription, message turnover, message splicing, translation, and protein cleavage from the cell surface all being independently regulated. This study examined both cell lines and primary cells to understand the developmental regulation of epigenetic changes at the TNF-alpha locus. We demonstrate that epigenetic modifications of the TNF-alpha locus occur both developmentally and in response to acute stimulation and, importantly, that they actively regulate expression. DNA demethylates early in development, beginning with the hematopoietic stem cell. The TNF-alpha locus migrates from heterochromatin to euchromatin in a progressive fashion, reaching euchromatin slightly later in differentiation. Finally, histone modifications characteristic of a transcriptionally competent gene occur with myeloid differentiation and progress with differentiation. Additional histone modifications characteristic of active gene expression are acquired with stimulation. In each case, manipulation of these epigenetic variables altered the ability of the cell to express TNF-alpha. These studies demonstrate the importance of epigenetic regulation in the control of TNF-alpha expression. These findings may have relevance for inflammatory disorders in which TNF-alpha is overproduced.

Epigenetic regulation of tumor necrosis factor alpha. Publishing Authors By Initials

KE Sullivan,AB Reddy,K Dietzmann,AR Suriano,VP Kocieda,M Stewart,M Bhatia,

For similar peptides: intercellular signaling peptides and proteins: cytokines: monokines: tumor necrosis factor-alpha research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: monokines: tumor necrosis factor-alpha research

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Epigenetic regulation of tumor necrosis factor alpha. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Molecular and cellular biology

VOLUME: 27

Page Numbers: 5147-60

Journal Abbreviation: Mol. Cell. Biol.

ISSN: 0270-7306

DAY: 21

MONTH: 05

YEAR: 2007

Epigenetic regulation of tumor necrosis factor alpha. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8109087

Epigenetic regulation of tumor necrosis factor alpha. Keywords Mesh Terms:

KEYWORDS: Tumor Necrosis Factor-alpha

MESH TERMS: genetics

Chemical & Substance for Abstract: Epigenetic regulation of tumor necrosis factor alpha. Information

Substance Name: Adenosine

Registry Number: 58-61-7

Grant and Affiliation Information for Epigenetic regulation of tumor necrosis factor alpha.

AFFILIATION: Division of Allergy and Immunology, Children's Hospital of Philadelphia, 34th St. and Civic Ctr. Blvd., Philadelphia, PA 19104, USA. sullivak@mail.med.upenn.edu

Country: United States

AGENCY: United States NIAID

GRANT: AI44127

ACRONYM: AI

MEDLINETA: Mol Cell Biol

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