Epigenetic regulation of neural gene expression and neuronal function.

Epigenetic regulation of neural gene expression and neuronal function. Research Abstract Details 

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Epigenetic regulation of neural gene expression and neuronal function. Abstract Text:

Jian Feng,Shaun Fouse,Guoping Fan,

The development and function of the CNS requires accurate gene transcription control in response to proper environmental signals. Epigenetic mechanisms, including DNA methylation, histone modifications, and other chromatin-remodeling events, are critically important in mediating precise neural gene regulation. This review focuses on discussing the role of DNA methylation and histone modifications in neural lineage differentiation, synaptic plasticity and neural behavior. We postulate that DNA methylation- and histone modification-mediated gene regulation is not only important for neural cell differentiation but also crucial for high-order cognitive functions such as learning and memory.

Epigenetic regulation of neural gene expression and neuronal function. Publishing Authors By Initials

J Feng,S Fouse,G Fan,

For similar nervous system: neurons research abstracts see: nervous system: neurons research

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MEDLINE DATE:

Epigenetic regulation of neural gene expression and neuronal function. Journal Published:

PUBLICATION TYPE: Review

Journal: Pediatric research

VOLUME: 61

Page Numbers: 58R-63R

Journal Abbreviation:

ISSN: 0031-3998

DAY: 3

MONTH: May

YEAR: 2007

Epigenetic regulation of neural gene expression and neuronal function. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100714

Epigenetic regulation of neural gene expression and neuronal function. Keywords Mesh Terms:

KEYWORDS: Neurons

MESH TERMS: physiology

Chemical & Substance for Abstract: Epigenetic regulation of neural gene expression and neuronal function. Information

Substance Name: DNA Modification Methylases

Registry Number: EC 2.1.1.-

Grant and Affiliation Information for Epigenetic regulation of neural gene expression and neuronal function.

AFFILIATION: Department of Human Genetics, David Geffen School of Medicine, University of California at Los Angeles, CA 90095, USA.

Country: United States

AGENCY: United States NINDS

GRANT: R01 NS51411

ACRONYM: NS

MEDLINETA: Pediatr Res

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