Epigenetic Programming of Stress Responses through Variations in Maternal Care.

Epigenetic Programming of Stress Responses through Variations in Maternal Care. Research Abstract Details 

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Epigenetic Programming of Stress Responses through Variations in Maternal Care. Abstract Text:

Eric W Fish,Dara Shahrokh,Rose Bagot,Christian Caldji,Timothy Bredy,Moshe Szyf,Michael J Meaney,

Early life experiences shape an individual's physical and mental health across the lifespan. Not surprisingly, an upbringing that is associated with adversity can produce detrimental effects on health. A central theme that arises from studies in human and nonhuman species is that the effects of adversity are mediated by the interactions between a mother and her young. In this review we describe some of the long-term effects of maternal care on the offspring and we focus on the impact of naturally occurring variations in the behavior of female rats. Of particular interest are mothers that engage in high or low amounts of licking/grooming (LG) and arched-back nursing (ABN) of their pups, but do so within the normal range for this species. Such variations in LG-ABN can alter the function of the hypothalamic-pituitary-adrenal (HPA) axis, and cognitive and emotional development by directly affecting the underlying neural mechanisms. At the heart of these mechanisms is gene expression. By studying the hippocampal glucocorticoid receptor gene, we have identified that maternal care regulates its expression by changing two processes: the acetylation of histones H3-K9, and the methylation of the NGFI-A consensus sequence on the exon 1(7) promoter. Sustained "maternal effects" appear elsewhere in biology, including plants, insects, and lizards, and may have evolved to program advantages in the environments that the offspring will likely face as adults. Given the importance of early life and parent-child interactions to later behavior, prevention and intervention programs should target this critical phase of development.

Epigenetic Programming of Stress Responses through Variations in Maternal Care. Publishing Authors By Initials

EW Fish,D Shahrokh,R Bagot,C Caldji,T Bredy,M Szyf,MJ Meaney,

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Epigenetic Programming of Stress Responses through Variations in Maternal Care. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Annals of the New York Academy of Sciences

VOLUME: 1036

Page Numbers: 167-80

Journal Abbreviation: Ann. N. Y. Acad. Sci.

ISSN: 0077-8923

DAY: 8

MONTH: Dec

YEAR: 2004

Epigenetic Programming of Stress Responses through Variations in Maternal Care. Information

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LANGUAGE: eng

NlmUniqueID: 7506858

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Grant and Affiliation Information for Epigenetic Programming of Stress Responses through Variations in Maternal Care.

AFFILIATION: Douglas Hospital Research Centre, 6875 boul. LaSalle, Montréal (Québec), Canada H4H 1R3. Michael.Meaney@mcgill.ca.

Country: United States

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MEDLINETA: Ann N Y Acad Sci

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