Epigenetic gene expression noise and phenotypic diversification of clonal cell populations.

Epigenetic gene expression noise and phenotypic diversification of clonal cell populations. Research Abstract Details 

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Epigenetic gene expression noise and phenotypic diversification of clonal cell populations. Abstract Text:

Thi My Anh Neildez-Nguyen, Parisot, Vignal,Philippe Rameau,Daniel Stockholm,Julien Picot, Allo,Christine Le Bec,Corinne Laplace,Andras Paldi,Thi My Anh Neildez-Nguyen, Parisot, Vignal,Philippe Rameau,Daniel Stockholm,Julien Picot, Allo,Christine Le Bec,Corinne Laplace,Andras Paldi,

Spontaneous emergence of phenotypic heterogeneity in cultures of genetically identical cells is a frequently observed phenomenon that provides a simple in vitro experimental system to model the problems of in vivo differentiation. In the present study, we have investigated whether stochastic variation of gene expression levels could contribute to phenotypic change in human cells. We have applied the two fluorescence-coding gene method and the expression variability of the two reporter genes to human cells in culture. We have quantified the portion of gene expression variation determined by global, promoter-specific, or by epigenetic sources. These two types of variation appear to contribute, in different ways, to the phenotypic diversification of clonal cell populations. Global, or promoter-specific, gene expression noise increases with cellular stress and contributes to the emergence of cellular diversity by diversifying the gene-expression levels. Epigenetic mechanisms act to increase the robustness of the cellular state by stabilizing gene transcription levels or by reinforcing the silenced state.

Epigenetic gene expression noise and phenotypic diversification of clonal cell populations. Publishing Authors By Initials

TM Neildez-Nguyen,A Parisot,C Vignal,P Rameau,D Stockholm,J Picot,V Allo,C Le Bec,C Laplace,A Paldi,TM Neildez-Nguyen,A Parisot,C Vignal,P Rameau,D Stockholm,J Picot,V Allo,C Le Bec,C Laplace,A Paldi,

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Epigenetic gene expression noise and phenotypic diversification of clonal cell populations. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Differentiation; research in biological diversity

VOLUME: 76

Page Numbers: 33-40

Journal Abbreviation: Differentiation

ISSN: 1432-0436

DAY: 6

MONTH: 09

YEAR: 2007

Epigenetic gene expression noise and phenotypic diversification of clonal cell populations. Information

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LANGUAGE: eng

NlmUniqueID: 401650

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Grant and Affiliation Information for Epigenetic gene expression noise and phenotypic diversification of clonal cell populations.

AFFILIATION: GENETHON, Centre National de la Recherche Scientifique UMR 8115 1 bis, rue de l'Internationale, 91002 Evry, France.

Country: England

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MEDLINETA: Differentiation

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