Epidermolysis bullosa acquisita associated with psoriasis vulgaris.

Epidermolysis bullosa acquisita associated with psoriasis vulgaris. Research Abstract Details 

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Epidermolysis bullosa acquisita associated with psoriasis vulgaris. Abstract Text:

D Hoshina,D Sawamura,T Nomura,S Tanimura,M Abe,T Onozuka,K Kodama,M Akiyama,H Shimizu,

We report a case of epidermolysis bullosa acquisita (EBA) associated with psoriasis vulgaris. A 71-year-old woman with psoriasis vulgaris developed subepidermal blisters on the extremities. Direct immunofluorescence demonstrated linear deposit of IgG at the basement membrane zone, which bound to the dermal side of normal human skin split with 1 mol/L NaCl. Immunoblot analysis using recombinant full-length type VII collagen detected a 290-kDa band, confirming the diagnosis of EBA. A literature search for previous reports found a few cases of EBA associated with psoriasis, and all cases, including our own, presented with widespread inflammatory vesicles and bullae, and responded to conventional therapy with corticosteroids and immunosuppressive agents. This study suggests that western blotting using recombinant full-length type VII collagen could be useful for diagnosis of EBA, and that EBA associated with psoriasis may have a tendency to be the inflammatory type.

Epidermolysis bullosa acquisita associated with psoriasis vulgaris. Publishing Authors By Initials

D Hoshina,D Sawamura,T Nomura,S Tanimura,M Abe,T Onozuka,K Kodama,M Akiyama,H Shimizu,

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Epidermolysis bullosa acquisita associated with psoriasis vulgaris. Journal Published:

PUBLICATION TYPE: Review

Journal: Clinical and experimental dermatology

VOLUME: 32

Page Numbers: 516-8

Journal Abbreviation: Clin. Exp. Dermatol.

ISSN: 0307-6938

DAY: 24

MONTH: 04

YEAR: 2007

Epidermolysis bullosa acquisita associated with psoriasis vulgaris. Information

Number of References: 7

LANGUAGE: eng

NlmUniqueID: 7606847

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Grant and Affiliation Information for Epidermolysis bullosa acquisita associated with psoriasis vulgaris.

AFFILIATION: Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan. hoshina@med.hokudai.ac.jp

Country: England

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MEDLINETA: Clin Exp Dermatol

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