Epidermal growth factor- and stress-induced loss of gap junctional communication is mediated by ERK-1/ERK-2 but not ERK-5 in rat liver epithelial cells.

Epidermal growth factor- and stress-induced loss of gap junctional communication is mediated by ERK-1/ERK-2 but not ERK-5 in rat liver epithelial cells. Research Abstract Details 

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Epidermal growth factor- and stress-induced loss of gap junctional communication is mediated by ERK-1/ERK-2 but not ERK-5 in rat liver epithelial cells. Abstract Text:

Kotb Abdelmohsen,Elisabeth Sauerbier,Niloofar Ale-Agha,Juliane Beier,Philippe Walter,Stefanie Galban,Dominik Stuhlmann,Helmut Sies,Lars-Oliver Klotz,Kotb Abdelmohsen,Elisabeth Sauerbier,Niloofar Ale-Agha,Juliane Beier,Philippe Walter,Stefanie Galban,Dominik Stuhlmann,Helmut Sies,Lars-Oliver Klotz,

Extracellular signal-regulated kinases (ERK) 1 and 2 as well as ERK-5 were previously suggested to phosphorylate connexin-43 and to contribute to the modulation of gap junctional intercellular communication (GJC). Exposure of rat liver epithelial cells to epidermal growth factor (EGF) or the redox cycling and alkylating agent menadione resulted in phosphorylation of connexin-43 and loss in GJC, both of which were abrogated by pharmacological inhibitors of ERK-1/2 activation, if used in concentrations that selectively abrogate phosphorylation of ERK-1/2 but not of ERK-5. Thus, EGF- or menadione-induced loss of GJC is mediated by ERK-1/2 but not ERK-5 in rat liver epithelial cells.

Epidermal growth factor- and stress-induced loss of gap junctional communication is mediated by ERK-1/ERK-2 but not ERK-5 in rat liver epithelial cells. Publishing Authors By Initials

K Abdelmohsen,E Sauerbier,N Ale-Agha,J Beier,P Walter,S Galban,D Stuhlmann,H Sies,LO Klotz,K Abdelmohsen,E Sauerbier,N Ale-Agha,J Beier,P Walter,S Galban,D Stuhlmann,H Sies,LO Klotz,

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Epidermal growth factor- and stress-induced loss of gap junctional communication is mediated by ERK-1/ERK-2 but not ERK-5 in rat liver epithelial cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biochemical and biophysical research communication

VOLUME: 364

Page Numbers: 313-7

Journal Abbreviation: Biochem. Biophys. Res. Commun.

ISSN: 1090-2104

DAY: 11

MONTH: 10

YEAR: 2007

Epidermal growth factor- and stress-induced loss of gap junctional communication is mediated by ERK-1/ERK-2 but not ERK-5 in rat liver epithelial cells. Information

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LANGUAGE: eng

NlmUniqueID: 372516

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AFFILIATION: Institut für Biochemie und Molekularbiologie I, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany.

Country: United States

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MEDLINETA: Biochem Biophys Res Commun

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