Epidemiology of apathy in older adults: the Cache County Study.

Epidemiology of apathy in older adults: the Cache County Study. Research Abstract Details 

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Epidemiology of apathy in older adults: the Cache County Study. Abstract Text:

Chiadi U Onyike,Jeannie-Marie E Sheppard,JoAnn T Tschanz,Maria C Norton,Robert C Green,Martin Steinberg,Kathleen A Welsh-Bohmer,John C Breitner,Constantine G Lyketsos,

OBJECTIVES: The objectives of this study are to describe the distribution of apathy in community-based older adults and to investigate its relationships with cognition and day-to-day functioning. METHODS: Data from the Cache County Study on Memory, Health and Aging were used to estimate the frequency of apathy in groups of elders defined by demographic, cognitive, and functional status and to examine the associations of apathy with impairments of cognition and day-to-day functioning. RESULTS: Apathy was measured with the Neuropsychiatric Inventory. Clinical apathy (Neuropsychiatric Inventory score > or = 4) was found in 1.4% of individuals classified as cognitively normal, 3.1% of those with a mild cognitive syndrome, and 17.3% of those with dementia. Apathy status was associated with cognitive and functional impairments and higher levels of stress experienced by caregivers. Among participants with normal cognition, apathy was associated with worse performance on the Mini-Mental State Examination, the Boston Naming and Animal Fluency tests, and the Trail Making Test-Part B. The association of apathy with cognitive impairment was independent of its association with Neuropsychiatric Inventory depression. CONCLUSIONS: In a cohort of community-based older adults, the frequency and severity of apathy is positively correlated with the severity of cognitive impairment. In addition, apathy is associated with cognitive and functional impairments in elders adjudged to have normal cognition. The results suggest that apathy is an early sign of cognitive decline and that delineating phenotypes in which apathy and a mild cognitive syndrome co-occur may facilitate earlier identification of individuals at risk for dementia.

Epidemiology of apathy in older adults: the Cache County Study. Publishing Authors By Initials

CU Onyike,JM Sheppard,JT Tschanz,MC Norton,RC Green,M Steinberg,KA Welsh-Bohmer,JC Breitner,CG Lyketsos,

For similar behavior and behavior mechanisms: behavior: behavioral symptoms: stress, psychological research abstracts see: behavior and behavior mechanisms: behavior: behavioral symptoms: stress, psychological research

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Epidemiology of apathy in older adults: the Cache County Study. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: The American journal of geriatric psychiatry : off

VOLUME: 15

Page Numbers: 365-75

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ISSN: 1064-7481

DAY: 3

MONTH: May

YEAR: 2007

Epidemiology of apathy in older adults: the Cache County Study. Information

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LANGUAGE: eng

NlmUniqueID: 9309609

Epidemiology of apathy in older adults: the Cache County Study. Keywords Mesh Terms:

KEYWORDS: Stress, Psychological

MESH TERMS: psychology

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Grant and Affiliation Information for Epidemiology of apathy in older adults: the Cache County Study.

AFFILIATION: Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA. conyike1@jhem.jhmi.edu

Country: United States

AGENCY: United States NIA

GRANT: R01-AG21136

ACRONYM: AG

MEDLINETA: Am J Geriatr Psychiatry

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