Epidemiology of alcohol-related liver and pancreatic disease in the United States.

Epidemiology of alcohol-related liver and pancreatic disease in the United States. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Epidemiology of alcohol-related liver and pancreatic disease in the United States. Abstract Text:

Alice L Yang,Shweta Vadhavkar,Gurkirpal Singh,M Bishr Omary,

BACKGROUND: The epidemiology of acute alcoholic pancreatitis (AP), chronic alcoholic pancreatitis (CP), acute alcoholic hepatitis (AH), and chronic alcoholic hepatitis with cirrhosis (CH) alone or in combination is not well described. To better understand alcohol-related liver and pancreas effects on and associations with different ethnic groups and sexes, we analyzed the trends of AP, CP, AH, CH, AP plus AH, and CP plus CH in the United States. METHODS: We examined discharge records from the Nationwide Inpatient Sample, the largest representative sample of US hospitals. Hospital discharges, case-fatality, and sex and race contributions were calculated from patients with discharge diagnoses of AP, CP, AH, CH, AP plus AH, or CP plus CH between 1988 and 2004. RESULTS: The distribution of overall hospital discharges per 100 000 persons between 1988 and 2004 was as follows: AP, 49.2; CP, 8.1; AH, 4.5; and CH, 13.7. Overall hospital discharges per 100 000 persons for AP plus AH were 1.8; and for CP plus CH, 0.32. There were higher male to female ratios for AH and CH, and less so for AP and CP. A markedly higher frequency of AP (63.5) and CP (11.3) was seen among blacks than among whites (AP, 29.6 and CP, 5.1), Hispanics (AP, 27.1 and CP, 3.7), Asians (AP, 12.8 and CP, 1.4), and American Indians (AP, 15.5 and CP, 2.3). This higher frequency remained stable between 1994 and 2004. Overall case fatality steadily decreased in all categories, but remains highest in CH (13.6%) with similar racial distributions. CONCLUSIONS: In the United States, AP is the most common discharge diagnosis among alcohol-related liver or pancreas complications, while CH has the highest case fatality rate and male to female ratio. Blacks have the highest frequency of alcohol-related pancreatic disease.

Epidemiology of alcohol-related liver and pancreatic disease in the United States. Publishing Authors By Initials

AL Yang,S Vadhavkar,G Singh,MB Omary,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Epidemiology of alcohol-related liver and pancreatic disease in the United States. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Archives of internal medicine

VOLUME: 168

Page Numbers: 649-56

Journal Abbreviation: Arch. Intern. Med.

ISSN: 0003-9926

DAY: 24

MONTH: Mar

YEAR: 2008

Epidemiology of alcohol-related liver and pancreatic disease in the United States. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372440

Epidemiology of alcohol-related liver and pancreatic disease in the United States. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Epidemiology of alcohol-related liver and pancreatic disease in the United States. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Epidemiology of alcohol-related liver and pancreatic disease in the United States.

AFFILIATION: Department of Medicine, Division of Gastroenterology and Hepatology, VA Palo Alto Health Care System and Stanford University, 3801 Miranda Ave 154J, Palo Alto, CA. mbishr@stanford.edu.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Arch Intern Med

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Epidemiology of alcohol-related liver and pancreatic disease in the United States Related Publications

• A comparison of chemoembolization endpoints using angiographic versus transcatheter intraarterial perfusion/MR imaging monitoring.
• Autophagy activation by rapamycin eliminates mouse Mallory-Denk bodies and blocks their proteasome inhibitor-mediated formation.
• Beyond a T-shape.
• Bright phosphorescence of a trinuclear copper(I) complex: luminescence thermochromism, solvatochromism, and "concentration luminochromism".
• Comparison between intravenous and intraarterial contrast injections for dynamic 3D MRI of liver tumors in the VX2 rabbit model.
• Comparison of Two Different Methods for Inoculating VX2 Tumors in Rabbit Livers and Hind Limbs.
• Comparison of transcatheter intraarterial perfusion MR imaging and fluorescent microsphere perfusion measurements during transcatheter arterial embolization of rabbit liver tumors.
• Effect of C-arm angiographic CT on transcatheter arterial chemoembolization of liver tumors.
• Effect of transcatheter arterial embolization on levels of hypoxia-inducible factor-1alpha in rabbit VX2 liver tumors.
• Epidemiology of alcohol-related liver and pancreatic disease in the United States.
• Fluorous metal-organic frameworks for high-density gas adsorption.
• From Mallory to Mallory-Denk bodies: what, how and why?
• Jahn-Teller distortion in the phosphorescent excited state of three-coordinate Au(I) phosphine complexes.
• Keratin 18 overexpression but not phosphorylation or filament organization blocks mouse Mallory body formation.
• Keratin mutation predisposes to mouse liver fibrosis and unmasks differential effects of the carbon tetrachloride and thioacetamide models.
• Keratin mutation primes mouse liver to oxidative injury.
• Keratins let liver live: Mutations predispose to liver disease and crosslinking generates Mallory-Denk bodies.
• MR Imaging Perfusion Mismatch: A Technique to Verify Successful Targeting of Liver Tumors during Transcatheter Arterial Chemoembolization.
• MR imaging assessment of changes in renal function with renal artery stent placement in swine.
• Mentoring the mentor: another tool to enhance mentorship.
• Monitoring of epithelial cell caspase activation via detection of durable keratin fragment formation.
• Rabbit VX2 Tumors as an Animal Model of Uterine Fibroids and for Uterine Artery Embolization.
• Rational Design of Macrometallocyclic Trinuclear Complexes with Superior pi-Acidity and pi-Basicity.
• Reciprocal keratin 18 Ser48 O-GlcNAcylation and Ser52 phosphorylation using peptide analysis.
• Renal artery stenosis in swine: feasibility of MR assessment of renal function during percutaneous transluminal angioplasty.
• The value of CT in determining potential instability of simple wedge-compression fractures of the lumbar spine.
• Transcatheter intraarterial perfusion: MR monitoring of chemoembolization for hepatocellular carcinoma--feasibility of initial clinical translation.
• Transglutaminase 2 regulates mallory body inclusion formation and injury-associated liver enlargement.
• Use of a combined MR imaging and interventional radiology suite for intraprocedural monitoring of uterine artery embolization.
• Uterine artery embolization: a treatment option for symptomatic fibroids in postmenopausal women.