Epicatechin gallate-induced expression of NAG-1 is associated with growth inhibition and apoptosis in colon cancer cells.

Epicatechin gallate-induced expression of NAG-1 is associated with growth inhibition and apoptosis in colon cancer cells. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Epicatechin gallate-induced expression of NAG-1 is associated with growth inhibition and apoptosis in colon cancer cells. Abstract Text:

Seung Joon Baek,Jong-Sik Kim,Felix R Jackson,Thomas E Eling,Michael F McEntee,Seong-Ho Lee,

There is persuasive epidemiological and experimental evidence that dietary polyphenolic plant-derived compounds have anticancer activity. Many laboratories, including ours, have reported such an effect in cancers of the gastrointestinal tract, lung, skin, prostate and breast. The catechins are a group of polyphenols found in green tea, which is one of the most commonly consumed beverages in the world. While the preponderance of the data strongly indicates significant antitumorigenic benefits from the green tea catechins, the potential molecular mechanisms involved remain obscure. We found that green tea components induce apoptosis via a TGF-beta superfamily protein, NAG-1 (Non-steroidal anti-inflammatory drug Activated Gene). In this report, we show that ECG is the strongest NAG-1 inducer among the tested catechins and that treatment of HCT-116 cells results in an increasing G(1) sub-population, and cleavage of poly (ADP-ribose) polymerase (PARP), consistent with apoptosis. In contrast, other catechins do not significantly induce NAG-1 expression, PARP cleavage or morphological changes at up to a 50-microM concentration. Furthermore, we provide evidence that ECG induces the ATF3 transcription factor, followed by NAG-1 induction at the transcriptional level in a p53-independent manner. The data generated by this study will help elucidate mechanisms of action for components in green tea and this information may lead to the design of more effective anticancer agents and informed clinical trials.

Epicatechin gallate-induced expression of NAG-1 is associated with growth inhibition and apoptosis in colon cancer cells. Publishing Authors By Initials

SJ Baek,JS Kim,FR Jackson,TE Eling,MF McEntee,SH Lee,

For similar proteins: dna-binding proteins: tumor suppressor protein p53 research abstracts see: proteins: dna-binding proteins: tumor suppressor protein p53 research

PUBMED ID PMID:

MEDLINE DATE:

Epicatechin gallate-induced expression of NAG-1 is associated with growth inhibition and apoptosis in colon cancer cells. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Carcinogenesis

VOLUME: 25

Page Numbers: 2425-32

Journal Abbreviation: Carcinogenesis

ISSN: 0143-3334

DAY: 12

MONTH: 08

YEAR: 2004

Epicatechin gallate-induced expression of NAG-1 is associated with growth inhibition and apoptosis in colon cancer cells. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8008055

Epicatechin gallate-induced expression of NAG-1 is associated with growth inhibition and apoptosis in colon cancer cells. Keywords Mesh Terms:

KEYWORDS: Tumor Suppressor Protein p53

MESH TERMS: metabolism

Chemical & Substance for Abstract: Epicatechin gallate-induced expression of NAG-1 is associated with growth inhibition and apoptosis in colon cancer cells. Information

Substance Name: Poly(ADP-ribose) Polymerases

Registry Number: EC 2.4.2.30

Grant and Affiliation Information for Epicatechin gallate-induced expression of NAG-1 is associated with growth inhibition and apoptosis in colon cancer cells.

AFFILIATION: Laboratory of Environmental Carcinogenesis, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, TN 37996, USA. sbaek2@utk.edu

Country: England

AGENCY: United States NIEHS

GRANT: K22ES011657

ACRONYM: ES

MEDLINETA: Carcinogenesis

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Epicatechin gallate-induced expression of NAG-1 is associated with growth inhibition and apoptosis in colon cancer cells Related Publications

• A differential response of two putative mammalian circadian regulators, mper1 and mper2, to light.
• Actual Conditions and Countermeasure of Yun-bian Old Men's Health.
• Aspirin changes the secretion rate and amino acid composition of human small intestinal mucin in subjects with ileal conduits.
• Bone morphogenetic protein-2 facilitates expression of chondrogenic, not osteogenic, phenotype of human intervertebral disc cells.
• Channel architecture in maltoporin: dominance studies with lamB mutations influencing maltodextrin binding provide evidence for independent selectivity filters in each subunit.
• Compensation. Costly to a fault.
• Design and feasibility of quick EXAFS scans for a 'broomstick' double-crystal monochromator at PLS beamline.
• Directed evolution of the lambda receptor of Escherichia coli through affinity chromatographic selection.
• Effects of dietary vitamin E supplementation on lipid oxidation and volatiles content of irradiated, cooked turkey meat patties with different packaging.
• Exclusion of high-molecular-weight maltosaccharides by lipopolysaccharide O-antigen of Escherichia coli and Salmonella typhimurium.
• Family decision making for elderly patients in the intensive care unit.
• Identification of an osteogenic protein-1 responsive element in the aggrecan promoter.
• Impairment of conjunctival glutathione secretion and ion transport by oxidative stress in an adenovirus type 5 ocular infection model of pigmented rabbits.
• Inactivation of the PTEN gene protein product is associated with the invasiveness and metastasis, but not angiogenesis, of breast cancer.
• Isolation, by affinity chromatography, of mutant escherichia coli cells with novel regulation of lamB expression.
• Longitudinal clivus fracture associated with trapped basilar artery: unusual survival with good neurological recovery.
• MPer1 and mper2 are essential for normal resetting of the circadian clock.
• Model construction on quality of family caregiving in the elderly.
• Nonredundant roles of the mPer1 and mPer2 genes in the mammalian circadian clock.
• Photoionization studies of sulfur radicals and products of their reactions.
• Posterior transarticular screw fixation for chronic atlanto-axial instability.
• Reciprocal regulation of haem biosynthesis and the circadian clock in mammals.
• Restoration of a loose implant supported crown: a case report.
• Significance of chronic epilepsy in glial tumors and correlation with surgical strategies.
• The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo.
• The effects of permeation enhancers on the surface morphology of the rat nasal mucosa: a scanning electron microscopy study.
• The influence of maltoporin affinity on the transport of maltose and maltohexaose into Escherichia coli.
• Tissue-specific expression, heat inducibility, and biological roles of two hsp16 genes in Caenorhabditis elegans.
• Up-regulation of MUC5AC and MUC5B mucin genes in chronic rhinosinusitis.
• [Expression of MUC3, MUC5AC, MUC6 and epidermal growth factor receptor in gallbladder epithelium according to gallstone composition]