Serine Endopeptidases

- A 3D model of Reelin subrepeat regions predicts Reelin binding to carbohydrates. Reelin is a large molecule of the extracellular matrix (ECM) which regulates neuronal positioning during the early stages of cortical development in...

- A conserved extended signal peptide region directs posttranslational protein translocation via a novel mechanism. Members of the type V secretion family are among the most prevalent secreted proteins in Gram-negative bacteria. A subset of this family, including Pet, the...

- A cross-reactive material positive variant of coagulation factor XI (FXIP520L) with a catalytic defect. Inherited deficiency of the trypsin-like protease factor (F) XI is associated with a mild to moderate bleeding diathesis. In most cases, FXI protein is...

- A novel human PACE4 isoform, PACE4E is an active processing protease containing a hydrophobic cluster at the carboxy terminus. PACE4 is a processing protease which processes the precursor protein to the mature protein. Currently, four PACE4 isoforms have been reported [Tsuji, A. et...

- Activation of EDTA-resistant gelatinases in malignant human tumors. Among the many proteases associated with human cancer, seprase or fibroblast activation protein alpha, a type II transmembrane glycoprotein, has two types of...

- Amino acid sequence around the reactive serine of cucumisin from melon fruit. Cucumisin is a diisopropyl fluorophosphate-sensitive enzyme. The inactivation by DFP is accompanied by the formation of 1 mol of labeled serine residue per...

- Amino acid sequence of a coagulant enzyme, flavoxobin, from Trimeresurus flavoviridis venom. The amino acid sequence of a coagulant enzyme, named flavoxobin, isolated from the venom of Trimeresurus flavoviridis (the habu snake) was determined by...

- Amino acid sequence of a lectin from Japanese frog (Rana japonica) eggs. The complete amino acid sequence and the location of disulfide bonds of a lectin from Japanese frog (Rana japonica) eggs, which specifically agglutinates...

- Amino acid sequence of an inhibitor from the silkworm (Bombyx mori) hemolymph against fungal protease. A novel protein protease inhibitor (FPI-F) which is highly specific for fungal proteases and subtilisin was isolated from the silkworm hemolymph, and its...

- Amino acid sequence of sweet-taste-suppressing peptide (gurmarin) from the leaves of Gymnema sylvestre. The complete amino acid sequence of a sweet-taste-suppressing peptide, gurmarin, from the leaves of Gymnema sylvestre was determined by the Edman analysis of...

- Amino acid sequence of Trimeresurus flavoviridis phospholipase A2. The amino acid sequence of phospholipase A2 from the venom of Trimeresurus flavoviridis (the Habu snake) was determined. The enzyme subunit has a molecular...

- Amino acid sequence studies on cyanogen bromide peptides of chicken caldesmon which bind to calmodulin. Three major calmodulin-binding cyanogen bromide peptides (fragments A, B, and D) were isolated from chicken gizzard muscle caldesmon and their amino acid...

- An evolutionarily conserved fission yeast protein, Ned1, implicated in normal nuclear morphology and chromosome stability, interacts with Dis3, Pim1/RCC1 and an essential nucleoporin. We identified a novel fission yeast gene, ned1(+), with pleiotropic mutations that have a high incidence of chromosome missegregation, aberrantly shaped...

- Analysis of a conformation-independent epitope and a conformational epitope in a protein: a study on cobrotoxin from Taiwan cobra venom. The antibodies against cobrotoxin were separated into two antibody preparations by successive affinity chromatographies on reduced and S-carboxymethylated...

- Bacterium-induced cleavage of IgA in nasopharyngeal secretions from atopic children. Immunoglobulin A forms the specific immune barrier of mucosal surfaces against microorganisms and potential allergens. Immunochemical studies of...

- Brain development and the genetics of brain development. The progress made in the understanding of the genetics of human brain malformations has lead to insight into the formation of brain and into mechanisms of...

- Catalytic activity is not required for secreted PCSK9 to reduce low density lipoprotein receptors in HepG2 cells. Proprotein convertase subtilisin/kexin type 9 (PCSK9), a member of the proteinase K subfamily of subtilases, promotes internalization and degradation of low...

- Cathepsin-G interferes with clearance of Pseudomonas aeruginosa from mouse lungs. The cystic fibrosis airway is susceptible to Pseudomonas aeruginosa infection, which stimulates an intense inflammatory response leading to airway...

- Cloning and expression of subtilisin amylosacchariticus gene. The gene encoding subtilisin Amylosacchariticus from Bacillus subtilis var. amylosacchariticus was isolated and the entire nucleotide sequence of the coding...

- Commonly dysregulated genes in murine APL cells. To identify genes that are commonly dysregulated in a murine model of acute promyelocytic leukemia (APL), we first defined gene expression patterns during...