rho GTP-Binding Proteins

- 18 wheeler regulates apical constriction of salivary gland cells via the Rho-GTPase-signaling pathway. Rho GTPase and its upstream activator, guanine nucleotide exchange factor 2 (RhoGEF2), have emerged as key regulators of actin rearrangements during...

- A brain serine/threonine protein kinase activated by Cdc42 and Rac1. A new brain serine/threonine protein kinase may be a target for the p21ras-related proteins Cdc42 and Rac1. The kinase sequence is related to that of the...

- A yeast two-hybrid system using Sp17 identified Ropporin as a novel cancer-testis antigen in hematologic malignancies. Since most intracellular proteins are expressed with their ligands, ligands of cancer-testis (CT) antigens may also be CT in their distribution. Applying...

- Abelson kinase (Abl) and RhoGEF2 regulate actin organization during cell constriction in Drosophila. Morphogenesis involves the interplay of different cytoskeletal regulators. Investigating how they interact during a given morphogenetic event will help us...

- Actin and Rho GTPases in herpesvirus biology. Viruses have evolved a variety of interactions with host cells to create an optimal niche for viral replication, persistence and spread. The actin...

- Actin assembly at membranes controlled by ARF6. The small GTPase, ADP-ribosylation factor-6 (ARF6), has been implicated in regulating membrane traffic and remodeling cortical F-actin. Using real-time video...

- Actin up: regulation of podocyte structure and function by components of the actin cytoskeleton. Podocytes of the renal glomerulus are unique cells with a complex cellular organization consisting of a cell body, major processes and foot processes....

- Adenoviral-mediated expression and local deposition of recombinant tenascin-C perturbs cell-dependent matrix contraction. BACKGROUND: To mimic the wound environment, we have developed a three-dimensional (3-D) fibrin-fibronectin (FN) matrix model that is formed in vitro from...

- Bordetella dermonecrotic toxin exerting toxicity through activation of the small GTPase Rho. Bordetella dermonecrotic toxin (DNT) is a virulence factor produced by bacteria belonging to the genus Bordetella. The toxin possesses novel transglutaminase...

- c-Abl interacts with the WAVE2 signaling complex to induce membrane ruffling and cell spreading. The Wiskott-Aldrich syndrome-related protein WAVE2 promotes Arp2/3-dependent actin polymerization downstream of Rho-GTPase activation. The...

- Catching a GEF by its tail. The activation of Rho GTPases is mediated by guanine-nucleotide exchange factors (GEFs), which catalyze the exchange of GDP for GTP. Rho-GEFs are a very...

- Cell biology. Integrins, rafts, Rac, and Rho.

- Cellular distribution and functions of wild-type and constitutively activated Dictyostelium PakB. Dictyostelium PakB, previously termed myosin I heavy chain kinase, is a member of the p21-activated kinase (PAK) family. Two-hybrid assays showed that PakB...

- Combined integrin activation and intracellular cAMP cause Rho GTPase dependent growth cone collapse on laminin-1. Cyclic nucleotides regulate the response of both developing and regenerating growth cones to a wide range of guidance molecules through poorly understood...

- Competitive binding of protein kinase Calpha to membranes and Rho GTPases. Previously, we have shown that protein kinase C (PKC) forms a direct high-affinity, isozyme-specific and membrane lipid-independent interaction with Rho...

- Constitutive p21-activated kinase (PAK) activation in breast cancer cells as a result of mislocalization of PAK to focal adhesions. Cytoskeletal remodeling is critical for cell adhesion, spreading, and motility. p21-activated kinase (PAK), an effector molecule of the Rho GTPases Rac and...

- Defective microtubule-dependent podosome organization in osteoclasts leads to increased bone density in Pyk2(-/-) mice. The protein tyrosine kinase Pyk2 is highly expressed in osteoclasts, where it is primarily localized in podosomes. Deletion of Pyk2 in mice leads to mild...

- Differential activation and function of Rho GTPases during Salmonella-host cell interactions. Salmonella enterica, the cause of food poisoning and typhoid fever, has evolved sophisticated mechanisms to modulate Rho family guanosine triphosphatases...

- Directional shear flow and Rho activation prevent the endothelial cell apoptosis induced by micropatterned anisotropic geometry. To study the roles of anisotropic cell morphology and directionality of mechanical force in apoptosis, the spreading of human umbilical vein endothelial...

- Disruption of RhoGDI and RhoA regulation by a Rac1 specificity switch mutant. Rho family GTPases are important regulators of the actin cytoskeleton. Activation of these proteins can be promoted by guanine nucleotide exchange factors...