Enzymatic removal of hyaluronan affects routing of axons in the mouse optic chiasm.

Enzymatic removal of hyaluronan affects routing of axons in the mouse optic chiasm. Research Abstract Details 

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Enzymatic removal of hyaluronan affects routing of axons in the mouse optic chiasm. Abstract Text:

Chung-Kit Chan,Jun Wang,Ling Lin,Yanli Hao,Sun-On Chan,

Perturbations of interaction of hyaluronan (HA) with its receptor CD44 cause multiple errors in axon routing at the mouse optic chiasm. To investigate this interaction further on the chiasm routing, we studied the axon routing after enzymatic removal of HA from slice preparations of the optic pathway. Hyaluronidase treatment produced an obvious reduction in midline crossing of the first generated axons in E13 chiasms, but had no influence on routing ofthe uncrossed axons in E15 and E16 slices. These findings support a direct role of HA, acting probably through CD44, on axon decussation during early phase of chiasm development, but argue against a direct function of HA on the turning of uncrossed axons in the mouse optic chiasm.

Enzymatic removal of hyaluronan affects routing of axons in the mouse optic chiasm. Publishing Authors By Initials

CK Chan,J Wang,L Lin,Y Hao,SO Chan,

For similar nervous system: neural pathways: afferent pathways: visual pathways research abstracts see: nervous system: neural pathways: afferent pathways: visual pathways research

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Enzymatic removal of hyaluronan affects routing of axons in the mouse optic chiasm. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Neuroreport

VOLUME: 18

Page Numbers: 1533-8

Journal Abbreviation: Neuroreport

ISSN: 0959-4965

DAY: 8

MONTH: Oct

YEAR: 2007

Enzymatic removal of hyaluronan affects routing of axons in the mouse optic chiasm. Information

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LANGUAGE: eng

NlmUniqueID: 9100935

Enzymatic removal of hyaluronan affects routing of axons in the mouse optic chiasm. Keywords Mesh Terms:

KEYWORDS: Visual Pathways

MESH TERMS: physiology

Chemical & Substance for Abstract: Enzymatic removal of hyaluronan affects routing of axons in the mouse optic chiasm. Information

Substance Name: Hyaluronoglucosaminidase

Registry Number: EC 3.2.1.35

Grant and Affiliation Information for Enzymatic removal of hyaluronan affects routing of axons in the mouse optic chiasm.

AFFILIATION: Department of Anatomy, The Chinese University of Hong Kong, Shatin, Hong Kong.

Country: England

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MEDLINETA: Neuroreport

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