Environmental toxins as modulators of antiviral immune responses.

Environmental toxins as modulators of antiviral immune responses. Research Abstract Details 

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Environmental toxins as modulators of antiviral immune responses. Abstract Text:

B Paige Lawrence,

Exposure to environmental contaminants has a profound effect on immune function, yet mechanistic understanding of how pollutants deregulate immune responses has, for many chemicals, remained elusive. Available data suggest that certain pollutants alter host immune responses and increase susceptibility to viral infection. In particular, data from a combination of epidemiological and animal studies show that exposure to dioxins, cigarette smoke, diesel exhaust and other air pollutants increase pathology associated with infection. Mechanistically, some of these chemicals disrupt the kinetics and efficacy of innate and adaptive responses to infection, whereas others influence viral latency. While there remain considerable gaps in our knowledge of the complex interactions between viruses, immune cells, and the host environment, these observations indicate that pollutants are important but overlooked contributors to susceptibility and pathogenesis of viral infections.

Environmental toxins as modulators of antiviral immune responses. Publishing Authors By Initials

BP Lawrence,

For similar virus diseases research abstracts see: virus diseases research

PUBMED ID PMID:

MEDLINE DATE:

Environmental toxins as modulators of antiviral immune responses. Journal Published:

PUBLICATION TYPE: Review

Journal: Viral immunology

VOLUME: 20

Page Numbers: 231-42

Journal Abbreviation: Viral Immunol.

ISSN: 0882-8245

DAY: 3

MONTH: 12

YEAR: 2007

Environmental toxins as modulators of antiviral immune responses. Information

Number of References: 109

LANGUAGE: eng

NlmUniqueID: 8801552

Environmental toxins as modulators of antiviral immune responses. Keywords Mesh Terms:

KEYWORDS: Virus Diseases

MESH TERMS: immunology

Chemical & Substance for Abstract: Environmental toxins as modulators of antiviral immune responses. Information

Substance Name: Receptors, Aryl Hydrocarbon

Registry Number: 0

Grant and Affiliation Information for Environmental toxins as modulators of antiviral immune responses.

AFFILIATION: Department of Environmental Medicine, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14642, USA. paige_lawrence@urmc.rochester.edu

Country: United States

AGENCY: United States NIEHS

GRANT: R21-ES013863

ACRONYM: ES

MEDLINETA: Viral Immunol

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