Environmental modulation of anxiety-related neuronal activity and behaviors.

Environmental modulation of anxiety-related neuronal activity and behaviors. Research Abstract Details 

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Environmental modulation of anxiety-related neuronal activity and behaviors. Abstract Text:

,Martin Otto,Andreas Zimmer, ,Martin Otto,Andreas Zimmer,

Enkephalin-deficient knockout mice, a genetic model of enhanced anxiety responses, and wild-type controls were housed in two separate facilities on the same campus using different caging systems. Stress reactivity was evaluated in these animals using a zero-maze test followed by c-Fos expression analysis in limbic brain regions. Animals with genetically or pharmacologically enhanced anxiety reared and tested in the same facility displayed similar behavioral reactivity and c-Fos induction. However, we found much stronger anxiety-related behavioral responses and higher c-Fos levels when animals were house in individually ventilated cages, independent of their genetic background.

Environmental modulation of anxiety-related neuronal activity and behaviors. Publishing Authors By Initials

A ,M Otto,A Zimmer,A ,M Otto,A Zimmer,

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Environmental modulation of anxiety-related neuronal activity and behaviors. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Behavioural brain research

VOLUME: 186

Page Numbers: 289-92

Journal Abbreviation: Behav. Brain Res.

ISSN: 0166-4328

DAY: 26

MONTH: 08

YEAR: 2007

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LANGUAGE: eng

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Grant and Affiliation Information for Environmental modulation of anxiety-related neuronal activity and behaviors.

AFFILIATION: Institute of Molecular Psychiatry, University of Bonn, Sigmund-Freud-Str. 25, 53125 Bonn, Germany.

Country: Netherlands

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MEDLINETA: Behav Brain Res

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