Environmental enrichment decreases the afterhyperpolarization in senescent rats.

Environmental enrichment decreases the afterhyperpolarization in senescent rats. Research Abstract Details 

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Environmental enrichment decreases the afterhyperpolarization in senescent rats. Abstract Text:

Ashok Kumar,Thomas Foster,

Previous research indicates that an age-related increase in the amplitude of the Ca2+-dependent, K+-mediated afterhyperpolarization (AHP) is related to cognitive decline. However, because the AHP is measured following completion of training, it is unclear whether the AHP amplitude is strictly dependent on biological aging or is modified by the training procedure. To address this distinction we examined the effect of environmental enrichment on the AHP amplitude. Young (5-8 months) and aged (22-24 months) male Fischer 344 rats were exposed to environmental enrichment conditions (EC) or maintained in individual cages (IC). Following 8-10 weeks of differential experience, sharp microelectrode current-clamp recordings were obtained in CA1 pyramidal neurons in hippocampal slices. Examination of the AHP demonstrated that the amplitude was significantly reduced in aged animals exposed to enriched conditions. The results indicate that the amplitude of the AHP in hippocampal pyramidal cells from aged animals is dependent on the history of experience and hippocampal activity.

Environmental enrichment decreases the afterhyperpolarization in senescent rats. Publishing Authors By Initials

A Kumar,T Foster,

For similar animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats research abstracts see: animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats research

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Environmental enrichment decreases the afterhyperpolarization in senescent rats. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Brain research

VOLUME: 1130

Page Numbers: 103-7

Journal Abbreviation: Brain Res.

ISSN: 0006-8993

DAY: 13

MONTH: 12

YEAR: 2006

Environmental enrichment decreases the afterhyperpolarization in senescent rats. Information

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LANGUAGE: eng

NlmUniqueID: 45503

Environmental enrichment decreases the afterhyperpolarization in senescent rats. Keywords Mesh Terms:

KEYWORDS: Rats

MESH TERMS: metabolism

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Grant and Affiliation Information for Environmental enrichment decreases the afterhyperpolarization in senescent rats.

AFFILIATION: Department of Neuroscience, McKnight Brain Institute, University of Florida, PO Box 100244, Gainesville, FL 32610-0244, USA.

Country: Netherlands

AGENCY: United States NIMH

GRANT: R01 MH059891-07

ACRONYM: MH

MEDLINETA: Brain Res

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